摘要
目的探讨龙琥醒脑颗粒治疗中轻型颅脑损伤后认知障碍的疗效及其对血清炎性因子和5-羟色胺(5-HT)的影响。方法选取2016年8月—2018年8月收治的中轻型颅脑损伤患者90例,均伴有认知障碍,根据随机数字表法分成治疗组和对照组,每组45例。对照组采用常规西药治疗,治疗组在此基础上加用龙琥醒脑颗粒,治疗12周。比较两组中医证候疗效,包括神昏谵语、瞳孔散大、软瘫乏力、四肢强直积分。分别在治疗前后采用《认知障碍初步评价表(COG-12)》评估两组患者的认知障碍改善效果。于治疗前后采集血样,检测血清白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及5-HT水平,并分析不良反应情况。结果两组治疗后神昏谵语、瞳孔散大、软瘫乏力、四肢强直积分均低于本组治疗前,且治疗组显著低于对照组(P<0.05)。两组治疗后COG-12评分低于本组治疗前,且治疗组较对照组显著下调(P<0.05)。两组治疗后血清IL-1β、IL-6、TNF-α、5-HT较本组治疗前下降,且治疗组低于对照组(P<0.05)。结论龙琥醒脑颗粒治疗中轻型颅脑损伤后认知障碍能进一步缓解中轻型颅脑损伤患者的症状,改善认知障碍,减轻机体炎症,并下调5-HT水平,未增加不良反应。
Objective To investigate the effect of Longhu Xingnao Granules on cognitive impairment after moderate and mild brain injury and its effect on serum inflammatory factors and 5-hydroxytryptamine(5-HT).Methods 90 patients with cognitive impairment after mild or moderate brain injury admitted to our hospital from August,2016 to August,2018 were divided into the treatment group and the control group by random number table,with 45 patients in each group.The control group was given conventional treatment,while the treatment group was additionally given Longhu Xingnao Granules based on the control group for 12 weeks.Improvement in the symptoms of delirium,dilated pupils,physical weakness,rigidity of limbs was observed and compared;improvement of cognitive impairment in both groups were evaluated by Cognitive-12(COG-12);blood sampling was collected to detect interleukin-1 beta(IL-1β),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)and 5-HT before and after treatment.Adverse reactions in both groups were observed.Results After treatment,both groups had reductions in the scores of delirium,dilated pupils,physical weakness,rigidity of limbs and the COG-12 score,and the treatment group was lower than the control group with significance(P<0.05).Both groups had reductions in the levels of serum IL-1β,IL-6,TNF-α,5-HT;and the treatment group was lower than the control group(P<0.05).Conclusion For cognitive impairment after moderate or mild brain injury,Longhu Xingnao Granules can alleviate symptoms,improve cognitive function,reduce inflammation and 5-HT level,without increasing the risk of adverse reactions.
作者
曾劲松
喻坚柏
罗刚
张占伟
余文运
ZENG Jin-song;YU Jian-bo;LUO Gang;ZHANG Zhan-wei;YU Wen-yun(Department of Encephalopathy,The First Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410007)
出处
《世界中西医结合杂志》
2020年第4期658-661,共4页
World Journal of Integrated Traditional and Western Medicine
基金
2017年湖南省教育厅科研项目(17C120)。
关键词
中轻型颅脑损伤
龙琥醒脑颗粒
认知障碍
炎性因子
5-羟色胺
Moderate or mild brain Injury
Longhu Xingnao Granules
Cognitive impairment
Inflammatory factors
5-HT
作者简介
通讯作者:喻坚柏,Emailyujianbai2478@sina.com。
