摘要
目的探讨急性颅脑损伤伴认知障碍患者应用果糖二磷酸钠联合奥拉西坦有效率及对血清胰岛素样生长因子-1(IGF-1)、脑损伤因子及血管内皮指标的影响。方法选取郑州大学第二附属医院2018-08-04-2020-12-04收治的107例颅脑损伤伴认知障碍患者作为研究对象,根据性别、年龄、损伤类型、文化程度组间均衡原则分为观察组和对照组。对照组53例给予奥拉西坦胶囊,观察组54例在此基础上增加果糖二磷酸钠。治疗2周后,对比2组患者有效率及认知功能、脑损伤因子、血管内皮损伤指标。结果观察组总有效率为94.44%,高于对照组的79.25%,χ^(2)=4.179,P=0.041;治疗后观察组中枢神经特异蛋白(S-100β)水平为(0.36±0.20)μg/L,低于对照组的(0.62±0.28)μg/L,t=5.518,P<0.001;人低氧诱导因子-1α(HIF-1α)水平为(281.39±31.62)μg/L,低于对照组的(315.41±34.90)μg/L,t=5.286,P<0.001;Tau蛋白水平为(254.13±31.65)pg/mL,低于对照组的(306.45±35.78)pg/mL,t=8.015,P<0.001。治疗后观察组简易精神状态检查表(MMSE)评分为(25.42±1.87)分,高于对照组的(22.69±1.29)分,t=8.804,P<0.001;血清IGF-1水平为(26.07±1.25)nmol/L,高于对照组的(23.14±0.93)nmol/L,t=13.773,P<0.001。治疗后观察组可溶性血栓调节蛋白(sTM)水平为(23.86±2.71)μg/L,低于对照组的(32.49±3.23)μg/L,t=14.983,P<0.001;血管性血友病因子(vWF)水平为(112.09±14.63)%,低于对照组的(136.34±17.87)%,t=7.687,P<0.001。结论果糖二磷酸钠联合奥拉西坦治疗急性颅脑损伤伴认知障碍患者效果确切,能够减轻脑损伤程度,提高认知功能,减轻血管内皮损伤。
Objective To explore the effects of fructose sodium diphosphate combined with olacetam on insulin-like growth factor-1(IGF-1),brain injury factor and vascular endothelial indexes in patients with acute craniocerebral injury with cognitive impairment.Methods A total of 107 patients with craniocerebral injury with cognitive impairment from August 4,2018 to December 4,2020 in our department were selected as the research objects,and divided into observation group and control group according to the balance principle of gender,age,injury type and education level.53 cases of control group were given olacetam capsule,and 54 cases of observation group were added fructose sodium diphosphate on this basis.After 2 weeks of treatment,cognitive function,brain injury factors and vascular endothelial injury indexes were compared between the two groups.Results The total effective rate of observation group was 94.44%,higher than that of control group(79.25%),χ^(2)=4.179,P=0.041.After treatment,the level of S-100βin the observation group was(0.36±0.20)μg/L,lower than that in the control group(0.62±0.28)μg/L,t=5.518,P<0.001.The level of human hypoxia inducible factor-1α(HIF-1α)was(281.39±31.62)μg/L,lower than that of the control group(315.41±34.90)μg/L,t=5.286,P<0.001.Tau protein level was(254.13±31.65)pg/ml,lower than that of the control group(306.45±35.78)pg/ml,t=8.015,P<0.001.After treatment,the score of mini-mental state examination(MMSE)in the observation group was 25.42±1.87,which was higher than that in the control group 22.69±1.29,t=8.804,P<0.001.The level of serum IGF-1 was(26.07±1.25)nmol/L,which was higher than that in the control group(23.14±0.93)nmol/L,t=13.773,P<0.001.After treatment,the level of soluble thrombomodulin(sTM)in the observation group was(23.86±2.71)μg/L,lower than that of the control group(32.49±3.23)μg/L,t=14.983,P<0.001.The level of von vwillebrand factor(vWF)was(112.09±14.63)%,which was lower than that in the control group(136.34±17.87)%,t=7.687,P<0.001.Conclusion Fructose sodium diphosphate combined with olacetam is effective in the treatment of patients with acute craniocerebral injury with cognitive impairment,which can reduce the degree of brain injury,improve cognitive function and reduce vascular endothelial injury.
作者
周明锴
杜航
张丹丹
王睿
宋豆豆
潘鹏宇
杨宵鹏
ZHOU Ming-kai;DU Hang;ZHANG Dan-dan;WANG Rui;SONG Dou-dou;PAN Peng-yu;YANG Xiao-peng(Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)
出处
《社区医学杂志》
CAS
2022年第2期74-77,共4页
Journal Of Community Medicine
关键词
果糖二磷酸钠
奥拉西坦
颅脑损伤
认知障碍
脑损伤因子
fructose sodium diphosphate
oraxitan
craniocerebral injury
cognitive impairment
brain injury factor
作者简介
通信作者:周明锴,男,河南新郑人,硕士,副主任医师,主要从事内科学的临床研究工作。E-mail:cazuan38@163.com
