摘要
目的探讨补肾助孕汤联合雌孕激素在宫腔粘连术后患者中的临床应用价值。方法选取2017年3月~2018年9月本院收治的宫腔粘连继发性不孕症患者80例为研究对象,按照随机数字表法分为两组,各40例。所有患者均行宫腔镜下宫腔粘连分离术,术后对照组给予雌孕激素周期性补充治疗,观察组则在对照组基础上联合使用补肾助孕汤。对所有入组者均电话及门诊随访12个月,比较干预后12个月月经周期第二天E2及FSH水平;比较干预后月经周期第二天检测子宫内膜厚度与宫颈黏液性状情况;统计随访过程中女性性生活质量标准量表(FSFI)评分变化情况及随访12个月两组妊娠情况。结果干预后月经周期第二天,观察组E2水平高于对照组,差异有统计学意义(P<0.05),FSH水平低于对照组,差异有统计学意义(P<0.05),干预后3个月,观察组子宫内膜厚度大于对照组,差异有统计学意义(P<0.05),宫颈黏液性状指数评分高于对照组,差异有统计学意义(P<0.05),干预后1个月及干预后3个月,观察组FSFI评分均显著高于对照组,差异有统计学意义(P<0.05),观察组妊娠率显著高于对照组,差异有统计学意义(P<0.05)。结论针对宫腔镜下粘连分离术患者,术后联合应用补肾助孕汤,能有效调节机体性激素水平,提高子宫内膜厚度,改善宫颈黏液性状,提升性生活质量,从而提高妊娠率。
Objective To investigate the clinical application value of Bushen Zhuyun decoction combined with estrogen and progesterone in patients after transcervical resection of adhesion.Methods 80 patients with secondary infertility due to intrauterine adhesions admitted and treated at our hospital from March 2017 to September 2018 were selected as the study objects,and divided into two groups according to the random number table method,with 40 patients in each group.All patients underwent hysteroscopic transcervical resection of adhesion.After surgery,the control group was given periodic estrogen and progesterone supplementation,while the observation group was combined with Bushen Zhuyun decoction on the basis of the control group.All participants were followed up by telephone and outpatient for 12 months.The levels of E2 and FSH on the second day of menstrual cycle 12 months after intervention were compared;the endometrial thickness and cervical mucus character detected on the second day of menstrual cycle after intervention were compared;the changes in the score of female sexual function index(FSFI)scale during the follow-up,as well as the pregnancy status of the two groups during the follow-up for 12 months,were analyzed.Results On the second day of menstrual cycle after intervention,E2 level in the observation group was higher than that in the control group,with statistically significant difference(P<0.05),while FSH level was lower than that in the control group,with statistically significant difference(P<0.05).At 3 months after intervention,endometrial thickness in the observation group was larger than that in the control group,with statistically significant difference(P<0.05),and cervical mucus character index score was higher than that in the control group,with statistically significant difference(P<0.05).At 1 month and 3 months after intervention,the FSFI score in the observation group was significantly higher than that in the control group,with statistically significant difference(P<0.05),and the pregnancy rate in the observation group was significantly higher than that in the control group,with statistically significant difference(P<0.05).Conclusion For patients undergoing hysteroscopic resection of adhesion,the combined application of Bushen Zhuyun decoction after surgery can effectively regulate the level of sex hormones in the body,improve the endometrial thickness,improve the cervical mucus character,enhance the quality of sexual life,thus improving the pregnancy rate.
作者
韩淑霞
HAN Shuxia(Department of Gynecology,Traditional Chinese Medicine Hospital of Akesu Prefecture in Xinjiang Uygur Autonomous Region,Xinjiang,Akesu 843000,China)
出处
《中国医药科学》
2020年第6期83-86,共4页
China Medicine And Pharmacy
关键词
补肾助孕汤
雌激素
孕激素
宫腔粘连
宫腔镜手术术后
不孕症
Bushen Zhuyun decoction
Estrogen
Progesterone
Intrauterine adhesion
After hysteroscopic surgery
Infertility
