摘要
目的观察阿司匹林+联合芬吗通应用于育龄期重度宫腔粘连(IUA)女性术后的效果。方法选取2018-09-10-2020-01-10南乐县妇幼保健院收治的102例育龄期重度IUA患者为研究对象,均行宫腔粘连分离术(TCRA),按照随机数字表法1∶1配对原则分为观察组和对照组,各51例。对照组给予芬吗通治疗,观察组加用阿司匹林治疗,对比2组疗效、子宫动脉血流参数[血流指数(FI)、血管化指数(VI)、血管化血流指数(VFI)、搏动指数(PI)及子宫动脉阻力指数(RI)]、经血量、子宫内膜厚度及形态,并统计试孕者妊娠情况。结果观察组总有效率为96.08%(49/51),高于对照组的82.35%(42/51),χ^(2)=4.993,P=0.026。术后3个月,观察组FI值为(28.18±1.73)、VI值为(3.60±0.57)、VFI值为(1.20±0.13),分别高于对照组的(23.55±3.72)、(3.23±0.39)、(0.90±0.10),均P<0.001;PI值为(1.28±0.15)、RI值为(1.03±0.12),分别低于对照组的(1.84±0.27)、(1.22±0.15),均P<0.001。术后3个月,观察组经血量为(57.08±4.47)mL,多于对照组的(46.14±4.43)mL,χ^(2)=8.426,P<0.001;子宫内膜厚度为(9.77±1.18)mm,厚于对照组的(8.26±1.20)mm,χ^(2)=4.418,P<0.001;A型子宫内膜率为62.75%(32/51),高于对照组的33.33%(17/51),χ^(2)=9.211,P=0.027。观察组妊娠分娩率为66.67%(12/18),高于对照组的28.57%(4/14),χ^(2)=4.571,P=0.033。结论阿司匹林+芬吗通应用于育龄期重度IUA女性术后疗效显著,可有效改善动脉血流,促进子宫内膜及月经恢复,对术后妊娠具有积极作用。
Objective To observe the postoperative effect of aspirin combined with fenmoton in women with severe intrauterine adhesions(IUA)of reproductive age.Methods A total of 102 patients with severe IUA of reproductive age who were admitted to our hospital from September 10,2018 to January 10,2020 were selected as research objects.All patients were underwent intrauterine adhesion separation(TCRA),and were divided into two groups according to the 1∶1 matching principle of random number table method.The control group(n=51)was given fenmetone,and the observation group(n=51)was given aspirin on the basis of control group.The curative effect,uterine artery blood flow index(FI),vascularization index(VI),vascularized blood flow index(VFI),pulsatility index(PI)and uterine artery resistance index(RI),menstrual blood volume,endometrial thickness and shape,and the pregnancy situation of those trying to conceive were counted.Results The total effective rate of the observation group was 96.08%(49/51),which was significantly higher than that of the control group,82.35%(42/51),χ^(2)=4.993,P=0.026.The FI value(28.18±1.73)and VI value(3.60±0.57)and VFI value(1.20±0.13)were higher than those of the control group(23.55±3.72,3.23±0.39,0.90±0.10),and the PI value(1.28±0.15)and RI value(1.03±0.12)were lower than those of the control group(1.84±0.27,1.22±0.15),all P<0.001;the menstrual blood volume(57.08±4.47)ml of the observation group was higher than that of the control group(46.14±4.43)ml(χ^(2)=8.426,P<0.00),and the endometrial thickness(9.77±1.18)mm thicker than that of the control group(8.26±1.20)mm(χ^(2)=4.418,P<0.001),and the rate of type A endometrium was 62.75%(32/51)significantly higher than that of the control group 33.33%(17/51),χ^(2)=9.211,P=0.027.
作者
李敬敏
王再英
樊雪蕊
LI Jing-min;WANG Zai-ying;FAN Xue-rui(Department of Obstetrics and Gynecology,Nanle County Maternal and Child Health Hospital,Nanle 457400,China)
出处
《社区医学杂志》
CAS
2022年第11期612-616,共5页
Journal Of Community Medicine
关键词
重度宫腔粘连
阿司匹林
芬吗通
子宫动脉血流参数
子宫内膜厚度
severe intrauterine adhesion
aspirin
fenmoton
uterine artery blood flow parameters
endometrial thickness
作者简介
通信作者:李敬敏,女,河南南乐人,主治医师,主要从事妇产科相关的临床研究工作。E-mail:tangmian369@163.com
