摘要
目的蛇伤膏治疗蝮蛇咬伤的疗效分析。方法收集安徽中医药大学第一附属医院急诊科就诊的蝮蛇咬伤患者84例,其中对照组13例,季德胜蛇药片外敷组25例,蛇伤膏外敷组46例。分析比较所有患者治疗前后各血液学指标包括天门冬氨酸氨基转移酶(aspartate transaminase,AST)、乳酸脱氢酶(lactate dehydrogenase,LDH)、α-羟丁酸脱氢酶(alpha-hydroxy-butyrate dehydrogenase,HBDH)、肌酸激酶(creatine kinase,CK)、肌酸激酶同工酶(creatine kinase-MB,CK-MB)变化情况;比较3组患者治疗前后肢体肿胀、疼痛积分结果,患肢肿胀、疼痛消失时间,并对各组患者平均治疗时间进行比较。结果与治疗前相比,季德胜蛇药片外敷组治疗后血液学指标AST、CK、CK-MB均显著下降,差异有统计学意义(P<0.05),但LDH和HBDH在治疗前后差异无统计学意义。与治疗前相比,蛇伤膏外敷组治疗后血液学指标AST、LDH、HBDH、CK以及CK-MB均显著下降,差异有统计学意义(P<0.05)。与治疗前相比,治疗后患者肢体肿胀、疼痛积分均明显下降(P<0.05),且与对照组相比,季德胜蛇药片外敷组和蛇伤膏外敷组治疗后患者肢体肿胀、疼痛积分下降程度明显优于对照组(P<0.05)。季德胜蛇药片外敷组与蛇伤膏外敷组相比治疗后患者肢体肿胀、疼痛积分下降程度差异无统计学意义(P>0.05)。与对照组相比,季德胜蛇药片外敷组和蛇伤膏外敷组治疗后患者肢体肿胀、疼痛消失用时以及平均治疗时间均短于对照组,差异有统计学意义(P<0.05)。季德胜蛇药片外敷组与蛇伤膏外敷组相比治疗后患者肢体肿胀、疼痛消失用时以及平均治疗时间差异无统计学意义(P>0.05)。结论蛇伤膏外敷等中西医结合可以有效治疗蝮蛇咬伤。
Objective To analyze the curative effect of snake injury ointment on Agkistrodon halys bite.Methods 100 patients with Agkistrodon halys bite in the Emergency Department of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were collected for the study,including 20 cases in the control group,40 cases in the Ji Desheng snake tablet external application group and 40 cases in the snake injury ointment external application group.The hematological indexes of all patients before and after the treatment were measured and compared,including aspartate aminotransferase(Aspartate transaminase,AST)and lactic dehydrogenase(Lactate dehydrogenase,LDH),α-hydroxybutyrate dehydrogenase(Alpha-hyd).The changes of roxy-butyrate dehydrogenase,HBDH),creatine kinase(Creatine kinase,CK)and creatine kinase isoenzyme(CreatineKinase-MB,CK-MB)were compared before and after the treatment.In addition,the results of limb swelling,pain score,swelling of affected limb and pain disappearance time were compared,and the average treatment time of each group was compared.Results Compared with before the treatment,AST,CK and CK-MB in the external application group of Jidesheng snake tablet decreased significantly(P<0.05),while LDH and HBDH had no significant difference before and after the treatment.Compared with before the treatment,AST,LDH,HBDH,CK and CK-MB in the external application group decreased significantly(P<0.05).Compared with before the treatment,the limb swelling and pain score of the patients after the treatment were significantly lower than those of the control group(P<0.05).Compared with the control group,the limb swelling and pain score of the patients in the external application group and the snake injury ointment group were significantly better(P<0.05).There was no significant difference in limb swelling and pain score between the external application group and the snake injury ointment group after the treatment(P>0.05).Compared with the control group,the limb swelling,pain disappearance time and average treatment time of the patients in the external application group and the snake injury ointment group were significantly shorter(P<0.05).There was no significant difference in limb swelling,pain disappearance time and average treatment time between the external application group and the snake injury ointment group after the treatment(P>0.05).Conclusion External application of snake injury ointment and other therapies of integrated traditional Chinese and western medicine can effectively treat Agkistrodon halys bite.
作者
杨德玉
王凯
李晗
韩宁林
YANG Deyu;WANG Kai;LI Han;HAN Ninglin(The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China)
出处
《标记免疫分析与临床》
CAS
2020年第3期436-439,共4页
Labeled Immunoassays and Clinical Medicine
基金
安徽中医药大学校级自然科学基金项目(编号:NO:2017zryb015)。
关键词
中西医结合
蝮蛇咬伤
蛇伤膏外敷
血液学指标
肿胀疼痛积分
治疗时间
Integrated traditional Chinese and western medicine
Agkistrodon halys bite
External application of snake wound ointment
Blood index
Swelling and pain score
Treatment time
作者简介
通讯作者:杨德玉,(1982—),男,硕士,主治医师,主要研究方向:中医内科,E-mail:crazybones@126.com。
