摘要
白芷为我国药食同源的大宗常用中药材之一,临床应用广泛,主要产于河南、河北、四川、浙江等地。白芷主要含有香豆素类、挥发油类、多糖类、生物碱类、氨基酸类等化学成分,具有镇痛抗炎、抗氧化、抗肿瘤、美白等药理作用。本文在对白芷化学成分和药理作用分析的基础上,基于质量标志物(Q-marker)概念,从植物亲缘学及化学成分特有性、传统药效、传统功效、成分可测性、熏硫加工等角度对白芷的质量标志物进行多方面分析预测,为白芷质量评价体系的建立和开发利用提供参考。
Angelica dahurica,as a medicinal and edible traditional Chinese medicine,is widely used in clinical practice.It is mainly cultivated in Henan,Hebei,Sichuang and Zhejiang provinces.At present,the study found that the main chemical components of this plant contained coumarins,volatile oil,polysaccharides,alkaloids,and amino acids and other components.It has anti-inflammatory,analgesic,anti-oxidant,anti-tumor,whitening effect and other pharmacological activities.In this paper,the chemical composition,pharmacological action of Angelica dahurica were summarized.Based on the core concepts of quality markers,the quality markers of Angelica dahurica were predicted and analyzed from the aspects of plant relativity and chemical component specificity,traditional medicinal properties,traditional efficacy,measurability of chemical components,Sulfur Fumigated,so as to provide reference for establishment and development of quality evaluation system of Angelica dahurica.
作者
邹菊英
苏维
潘意
崔姣
Zou Juying;Su Wei;Pan Yi;Cui Jiao(The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,China;Department of Periodical Press,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第7期2535-2548,共14页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
湖南省自然科学基金委员会科药联合基金(2021JJ80062):金蓉颗粒经Wnt/β-catenin信号通路靶向抑制乳腺癌干细胞特性的机制研究,负责人:崔姣
湖南省自然科学基金委员会青年基金项目(2022JJ40326):基于PI3K/AKT通路和自噬调节研究白芷有效成分调控CTSD诱导的黑色素降解的作用机制,负责人:潘意
湖南省中医药管理局湖南省中医药科研计划青年项目(2021186):基于细胞自噬途径的黑色素降解机制的研究及白芷有效成分的干预,负责人:潘意。
关键词
白芷
化学成分
药理作用
质量标志物
质量控制
Angelica dahurica
Chemical composition
Pharmacological effect
Quality markers(Q-markers)
Quality control
作者简介
通讯作者:崔姣,硕士研究生,副主任药师,主要研究方向:中药药理学与临床中药学。
