摘要
Herbal medicines play a crucial role in the healthcare system in China and other East Asian countries,and also have been used as alternative medicines in most Western countries[1-3].However,in most cases,the metabolic fates of herbal constituents and their effects on drug metabolism or endogenous metabolism in the human body have not been well-investigated[4-5].Notably,the concomitant use of herbal medicines may lead to clinically relevant herb-drug interactions or adverse reactions or even metabolic disorders,when some herbs are co-administrated with those drugs with narrow therapeutic indices(e.g.warfarin,digoxin,thyroid hormones and some anticancer agents)[6-8].
基金
supported by the National Key Research and Development Program of China(No.2017YFC1700200)
作者简介
Corresponding author:GE Guang-Bo,has been working in Shanghai University of Traditional Chinese Medicine as a full professor and the vice dean of Institute of Interdisciplinary Medicine since 2017.His current researches are focused on drug metabolism and herb-drug interactions.His representative achievements have been published in many top journals,such as J.Am.Chem.Soc.,Angew.Chem.Int.Ed.,Chem.Sci.,Biosens.Bioelectron.,ACS Applied Materials&Interfaces,J.Med.Chem.,Anal.Chem.,Chem.Commun.,et al.Now he is the editorial board member of more than 10 scientific journals,such as Acta Pharmaceutica Sinica B,Journal of Ethnopharmacology,Chinese Chemical Letters,Chinese Journal of Natural Medicines and Current Drug Delivery.E-mail:geguangbo@shutcm.edu.cn。
