摘要
目的探讨帕罗西汀治疗帕金森病伴发抑郁的临床效果。方法选取2018年1月~2019年1月我院收治的60例帕金森病伴发抑郁患者作为研究对象,按照随机数字分配原则分为观察组和对照组,每组各30例。对照组给予常规治疗,观察组在对照组基础上联合帕罗西汀片治疗,均持续治疗8周。比较两组治疗前后帕金森病统一评定量表(UPDRS)评分和汉密尔顿抑郁量表(HAMD)评分。结果观察组治疗后8周的UPDRS评分低于对照组,差异有统计学意义(P<0.05)。观察组治疗后4、8周的HAMD评分低于对照组,差异均有统计学意义(P<0.05)。结论应用帕罗西汀治疗帕金森病伴发抑郁患者,能缓解患者的症状和抑郁情绪,值得临床推广应用。
Objective To investigate the clinical effect of Paroxetine in the treatment of Parkinson′s disease with depression.Mehods Sixty patients with Parkinson′s disease accompanied by depression who were admitted to our hospital from January 2018 to January 2019 were selected as the research subjects,they were divided into observation group and control group according to the random number allocation principle,with 30 cases in each group.The control group was given routine treatment,and the observation group was treated with Paroxetine Tablets on the basis of the control group for 8 weeks.The unified Parkinson′s disease rating scale(UPDRS)and Hamilton depression scale(HAMD)scores were compared before and after treatment.Results The UPDRS score of the observation group was lower than that of the control group 8 weeks after treatment,the difference was statistically significant(P<0.05).The HAMD score of the observation group was lower than that of the control group at 4 and 8 weeks after treatment,the differences were statistically significant(P<0.05).Conclusion The application of Paroxetine in the treatment of Parkinson′s disease with depression can alleviate the symptoms and depression of patients,which is worthy of clinical application.
作者
陈新潮
CHEN Xin-chao(Department of Psychiatry,Xiamen Xianyue Hospital,Fujian Province,Xiamen361001,China)
出处
《中国当代医药》
2020年第4期66-68,共3页
China Modern Medicine
关键词
帕金森病
抗抑郁药
帕罗西汀
抑郁障碍
Parkinson′s disease
Anti-depressant
Paroxetine
Depressive disorder
作者简介
陈新潮(1976-),男,湖北黄冈人,本科,副主任医师,研究方向:精神疾病的诊治。
