摘要
铁元素在维持机体氧气运输、电子传递等正常生理功能方面发挥着重要作用.但如铁摄入过多,多余铁离子会通过Fenton反应催化氧自由基生成,同时启动一系列的自由基连锁反应,从而导致脂质过氧化及DNA损伤.而氧化应激可能是子痫前期发病机制之一.因此,铁超载与子痫前期的相关性逐渐受到关注,本文总结铁超载与子痫前期发病的相关文章,探讨铁超载在氧化应激中的作用及其参与子痫前期发病的可能机制.
Iron plays an important role in maintaining normal physiological functions of oxygen transportation and electron transfer in the body.However,excessive iron intake will induce the generation of oxygen radicals through Fenton reaction and result in free radical chain reactions,causing lipid peroxidation and DNA damage.Oxidative stress is also known as one of the causes of preeclampsia.Therefore,the correlation between iron overload and preeclampsia has attracted more attention.Relevant publications were reviewed to discuss the potential mechanisms of iron overload under oxidative stress in the pathogenesis of preeclampsia.
作者
董捷
颜建英
张勤建
Dong Jie;Yan Jianying;Zhang Qinjian(Graduate School of Clinical Medicine,Fujian Medical University,Fuzhou 350122,China;Department of Obstetrics and Gynecology,Fujian Maternal and Child Health Hospital,Affiliated Hospital of Fujian Medical University,Fuzhou 350001,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2019年第11期812-816,共5页
Chinese Journal of Perinatal Medicine
基金
福建省科技厅引导性项目(2018Y0005)
福建省医学创新课题(2017-CX-11)
福建省2014年临床重点专科(西医类别)建设项目(闽卫医政函[2015]593号)。
关键词
先兆子痫
铁
氧化性应激
Pre-eclampsia
Iron
Oxidative stress
作者简介
通信作者:颜建英,Email:yanjy2004@126.com,电话:0591-86329265。
