摘要
目的观察丁苯酞联合阿替普酶溶栓治疗急性脑梗死的疗效及血清炎症因子的变化。方法采集我院2014年5月至2018年10月神经科治疗的63例急性脑梗死(ACI)患者,分为2组,对照组30例施予阿替普酶溶栓治疗,观察组33例在其基础注入丁苯酞注射液治疗,比较2组疗效及血清炎症因子。结果观察组2周治疗总有效率比对照组更高(P<0.05);观察组治疗后脑梗死面积(11.1±2.0)cm2相较于对照组(13.1±1.2)cm2减少,且美国国立卫生研究院卒中量表(NIHSS)评分(4.1±1.1)分,相较于对照组(8.5±1.5)低(P<0.05);观察组治疗后C反应蛋白(CRP)(7.4±1.1)mg/L、IL-8(24.9±1.1)ng/L、IL-10(9.3±1.0)ng/L、降钙素原(PCT)(4.0±1.8)μg/L水平相较于对照组[CRP(13.8±1.4)mg/L、IL-8(30.8±1.5)ng/L、IL-10(11.0±0.9)ng/L、PCT(5.6±2.3)μg/L]均降低(P<0.05)。结论ACI通过阿替普酶与丁苯酞联合治疗,不仅能提高临床疗效缩小梗死面积,改善脑神经功能,还能缓解炎症反应,无明显不良反应。
Objective To observe the efficacy of butylphthalide combined with alteplase in the treatment of acute cerebral infarction(ACI)and serum inflammatory factors.Methods The clinical data of 63 patients with ACI treated by neurology were collected in our hospital from May 2014 to October 2018.The patients were divided into two groups,the 30 patients in the control group were treated with alteplase thrombolytic therapy.And other 33 patients in the observation group,which given the injection of butylphthalide on the basis of control group,then the efficacy of both groups and serum inflammatory factors were compared.Results The total effective rate of the observation group was higher than that of the control group at two weeks(P<0.05).The cerebral infarct size in the observation group was(11.1±2.0)cm2,which lower than that of the control group(13.1±1.2)cm2,and the NIHSS score(4.1±1.1)points was also lower than the control group(8.5±1.5)(P<0.05).Compared with the control group[CRP(13.8±1.4)mg/L,IL-8(30.8±1.5)ng/L,IL-10(11.0±0.9)ng/L,PCT(5.6±2.3)μg/L],the CRP(7.4±1.1)mg/L,IL-8(24.9±1.1)ng/L,IL-10(9.3±1.0)ng/L,PCT(4.0±1.8)μg/L in treatment group was reduced after the study(P<0.05).Conclusion The ACI combined with treatment with rituximab and butylphthalide could not only reduce infarct size,improve brain function,but also relieve inflammation,which has no obvious adverse reactions,and improve clinical efficacy.
作者
李康睿
叶民
Li Kangrui;Ye Min(Department of Neurology,Mingji Hospital,Nanjing Medical University,Jiangsu 210019,China)
出处
《山西医药杂志》
CAS
2019年第19期2347-2349,共3页
Shanxi Medical Journal
关键词
脑梗塞
血栓溶解疗法
阿替普酶
丁苯酞
神经功能
炎症反应
Brain infarction
Thrombolytic therapy
Alteplase
Butylphthalide
Neurological function
Inflammatory response
