摘要
目的:研究抑郁症患者治疗中文拉法辛联合氟西汀对临床疗效、血清学指标和神经递质的影响.方法:选取2015年10月至2017年1月于我院就诊的共抑郁症患者168例作为研究对象,按简单随机分组法将所有患者分为对照组(n=82例)和研究组(n=86例).其中对照组患者采用氟西汀治疗,研究组患者采用氟西汀联合文拉法辛治疗.对比两组患者治疗前后SF-36评分、HAMD评分、血清学指标和神经递质指标等.结果:两组患者治疗前SF-36评分对比无显著性差异(P>0.05),研究组患者治疗后4周、治疗后8周的SF-36评分均明显高于对照组,且均有统计学差异(P<0.05),两组患者治疗后4周、治疗后8周SF-36评分与各自治疗前对比均有统计学差异(P<0.05).两组患者治疗前HAMD评分对比无显著性差异(P>0.05),研究组患者治疗后4周、治疗后8周的HAMD评分明显高于对照组,且均有统计学差异(P<0.05),两组患者治疗后4周、治疗后8周HAMD评分与各自治疗前对比均有统计学差异(P<0.05).两组患者治疗前血清学指标TNF-α、IL-1β、IL-6等对比无显著性差异(P>0.05),研究组患者治疗后4周、治疗后8周的血清学指标TNF-α、IL-1β、IL-6等对比明显低于对照组,且均有统计学差异(P<0.05),两组患者治疗后4周、治疗后8周血清学指标TNF-α、IL-1β、IL-6等与各自治疗前对比均有统计学差异(P<0.05).两组患者治疗前神经递质指标Glu、NE、Ach、DA、5-HT和GABA等指标对比无统计学差异(P>0.05),研究组患者治疗后4周、治疗后8周的Glu明显低于对照组,NE、Ach、DA、5-HT和GABA等神经递质指标明显高于对照组,且均有统计学差异(P<0.05),两组患者治疗后4周、治疗后8周的Glu、NE、Ach、DA、5-HT和GABA等神经递质指标与各自治疗前对比均有统计学差异(P<0.05).结论:文拉法辛的作用机制与细胞因子表达和调节神经递质有关,且疗效确切,可明显改善患者生活质量,促进抑郁症状缓解,值得临床推广.
Objective: Research the clinical efficacy , serological indexes and neutrotransmitter of Venlafaxine in the treatment of depression . Methods: Select 168 depression patients between October 2015 and January 2017 of our hospital , divided them into two groups called control group and research group randomly, the control group was taken fluoxetine , while research group was combined with Venlafaxine , compared the SF-36 score , HAMD score , serological indexes and neutrotransmitter factors of two groups before and after treatment . Results: The SF-36 score of two groups before treatment had no statistical difference(P>0.05),the SF-36 score of research group 4 weeks and 8 weeks after treatment were both much higher than control group , and had statistical difference(P<0.05),the SF-36 score of two groups 4 weeks and 8 weeks after treatment all had statistical difference with pre-treatment respectively(P<0.05).The HAMD score of two groups had no statistical difference(P>0.05),the HAMD score of research group 4 weeks and 8 weeks after treatment were both much higher than control group , and had statistical difference(P<0.05),the HAMD score of two groups 4 weeks and 8 weeks after treatment all had statistical difference with pre-treatment respectively(P<0.05).The serological indexes of two groups such as TNF-α、IL-1β、IL-6 had no statistical difference(P>0.05),the TNF-α、IL-1β、IL-6 of research group 4 weeks and 8 weeks after treatment were both much lower than control group , and had statistical difference(P<0.05),the TNF-α、IL-1β、IL-6 level of two groups 4 weeks and 8 weeks after treatment all had statistical difference with pre-treatment respectively(P<0.05).The neutrotransmitter indexes such as Glu、NE、Ach、DA、5-HT and GABA of two groups before treatment had no statistical difference(P>0.05),Glu level of research group 4 weeks and 8 weeks after treatment were both much lower than control group , NE、Ach、DA、5-HT and GABA levels of research group of 4 weeks and 8 weeks after treatment were all much higher than control group , and had statistical difference(P<0.05),Glu、NE、Ach、DA、5-HT and GABA levels of two groups of 4 weeks and 8 weeks after treatment had statistical difference with pre-treatment respectively(P<0.05). Conclusion: The function mechanism of Venlafaxine is related to the expression of cytokines and the regulation of neutrotransmitters ,and the effect is accurate , which can significantly improve the quality of life of patients and promote the alleviation of depression symptoms , and is worthy of clinical promotion.
作者
刘涛
钟艳丽
LIU Tao(Chongqing Mental Health Center, Chongqing 400000, China)
出处
《河北医学》
CAS
2019年第8期1316-1321,共6页
Hebei Medicine
基金
重庆市科技计划项目,(编号:201410364)
关键词
抑郁症
文拉法辛
生活质量
HAMD
神经递质
脑涨落仪
depression
Venlafaxine
Quality of life
HAMD
Neutrotransmitter
Encephalofluctuograph
作者简介
通讯作者:钟艳丽.
