摘要
目的:探讨氟伏沙明、度洛西汀治疗60岁首发重度抑郁症(MDD)患者的疗效。方法:选取2019年3月~2021年3月本院收治的86例60岁后首发MDD患者为研究对象,采用随机数字表法分为氟伏沙明组与度洛西汀组,每组43例。以汉密尔顿抑郁量表(HAMD)评分、核心因子、躯体因子评估临床疗效;采用Snaith快感缺失量表(SHAPS)评估患者快乐能力;以不良反应量表(TESS)评估药物不良反应发生情况。结果:与治疗前相比,治疗1周、3周及6周后两组的HAMD总评分、核心因子评分以及躯体化因子评分均随治疗时间延长呈下降趋势(P<0.05),各时间点两两比较均有统计学差异(P<0.05)。治疗后,两组SHAPS评分整体均随治疗时间延长呈下降趋势(P<0.05);治疗3周后,SHAPS评分基本保持稳定,且与治疗6周后比较无统计学差异(P>0.05)。两组临床疗效比较无统计学差异(P>0.05)。两组治疗期间不良反应发生率比较无统计学差异(P>0.05)。结论:度洛西汀、氟伏沙明均可有效治疗老年MDD,且疗效相近、安全性均较高。
Objective:To discuss the effi cacy of fl uvoxamine and duloxetine in the patients with fi rst-episode major depressive disorder(MDD)over 60 years old.Methods:A total of 86 patients with first-episode MDD over 60 years old in our hospital from March 2019 to March 2021 were selected,and classifi ed into fl uvoxamine group and duloxetine group according to random number table methods,each group with 43 cases.The clinical effi cacy was evaluated using Hamilton depression scale(HAMD)score,the core factor scoreand somatization factor score.Snaith-Hamilton pleasure scale(SHAPS)was used to assess the happiness ability,and treatment emergent symptom scale(TESS)was used to evaluate the adverse reactions.Results:Compared with before treatment,score of HAMD,core factor score and somatization factor score of the two groups after 1 week,3 weeks and 6 weeks of treatment showed a sequential decrease with the extension of treatment time(P<0.05),and the scores demonstrated statistical diff erence among each time point(P<0.05).After treatment,the overall scores of SHAPS scale in both groups showed a downward trend over time(P<0.05).After 3 weeks of treatment,the SHAPS score remained basically stable.There was no signifi cant difference in SHAPS score between 6 weeks after treatment and 3 weeks after treatment(P>0.05).No signifi cant diff erence was found between two groups in terms of clinical effi cacy and adverse reactions(all P>0.05).Conclusion:Both fl uvoxamine and duloxetine are eff ective in the treatment of fi rst-episode MDD patients over 60 years old,and the clinical effi cacy was similar and the safety was high.
作者
万宏颖
王珊
武胜
佟靓
WAN Hong-ying;WANG Shan;WU Sheng;TONG Liang(Department of Psychiatry,Zhengzhou Eighth People’s Hospital,Zhengzhou 450006,China;Department of Psychology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450006,China;Department of Geriatric,Mental Health Center Affiliated to Kunming Medical University,Kunming 650000,China)
出处
《中国合理用药探索》
2022年第10期47-51,共5页
Chinese Journal of Rational Drug Use
基金
云南省科技厅-昆明医科大学应用基础研究联合专项基金[2019FE001(-107)]。
关键词
氟伏沙明
度洛西汀
60岁后
首发重度抑郁症
疗效
fluvoxamine
duloxetine
over 60 years old
fi rst-episode major depressive disorder
effi cacy
作者简介
万宏颖,女,主治医师,专业方向:精神分裂症、双相情感障碍。E-mail:240735065@qq.com;通讯作者:佟靓,男,主治医师,专业方向:老年精神病学。E-mail:kmtorgliang@163.com。
