摘要
目的探讨中药联合化疗在中晚期非小细胞肺癌治疗中的减毒增效作用。方法选择2016年1月至2018年1月辽宁省肿瘤医院及辽宁中医药大学附属第二医院收治的80例患者,随机分为治疗组及对照组。对照组40例,应用紫杉醇+卡铂方案化疗治疗;治疗组40例,应用中药联合化疗治疗。比较两组患者中医症状评分情况,T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)及NK细胞,肿瘤标志物细胞角蛋白19片段(CYERA21-1)、鳞状细胞癌抗原(SCCA)、癌胚抗原(CEA)及毒副作用。结果治疗后,治疗组症状评分降低(P<0.01),而对照组症状评分升高(P<0.01),且组间比较差异有统计学意义(P<0.01)。治疗后,两组患者血红蛋白、白细胞及血小板值降低,且组间比较差异有统计学意义(P<0.05)。治疗后,治疗组CD3^+、CD4^+、CD4^+/CD8^+、NK细胞百分比均升高(P<0.05),且两组比较差异有统计学意义(P<0.05)。治疗前,两组患者肿瘤标志物(CEA、SCCA、CYERA21-1)比较差异无统计学意义(P>0.05);治疗后,两组上述指标水平均显著降低(P<0.05),组间比较差异无统计学意义(P>0.05)。结论中药联合化疗具有减毒增效的作用,对于改善临床症状、减轻毒副作用有一定的效果。
Objective To explore the attenuating and synergistic effect of traditional Chinese medicine(TCM) combined with chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC).Methods Totally 80 patients with advanced NSCLC admitted to Liaoning Cancer Hospital and the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were randomly divided into treatment group and control group,40 cases in each group.Control group was given Taxol and platinum chemotherapy,while treatment group was treated with TCM combined with chemotherapy.The TCM symptom scores,levels of T lymphocyte subsets(CD3^+,CD4^+ and CD4^+/CD8^+) and NK cells,tumor marker cytokeratin 19 fragment(CYERA21-1),squamous cell carcinoma antigen(SCCA) and carcinoembryonic antigen(CEA),and the toxic side effects were compared between the two groups.Results After treatment,the symptom score of treatment group was decreased significantly(P<0.01),while the score of control group was increased(P<0.01),there being significant differences between the two groups(P<0.01).After treatment,the value of hemoglobin,white blood cell and platelet in the two groups was significantly decreased(P<0.01),and the difference between the two groups was significant(P<0.01);the percentages of CD3^+,CD4^+,CD4^+/CD8^+ and NK cells in treatment group were increased(P<0.01),and the difference was significant compared with that in control group(P<0.05).There were no significant differences in tumor markers(CEA,SCCA and CYERA21-1) between the two groups before treatment(P>0.05),and the indexes in both groups were decreased after treatment(P<0.05),there being no significant difference between the two groups(P>0.05).Conclusion TCM combined with chemotherapy has attenuating and synergistic effect in the treatment of advanced NSCLC,which has certain effects on clinical symptoms and side effects.
作者
周禄荣
李康
武晓彬
周文波
李秋华
ZHOU Lu-rong;LI Kang;WU Xiao-bin;ZHOU Wen-bo;LI Qiu-hua(Department of Oncology,the Second Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China;Department of Integrated Chinese and Western Medicine,Liaoning Cancer Hospital,Shenyang 110042,China)
出处
《实用药物与临床》
CAS
2019年第6期593-596,共4页
Practical Pharmacy and Clinical Remedies
基金
2017年辽宁省中医药临床学(专)科能力建设项目
2018年辽宁省博士启动基金(20180540043)
关键词
非小细胞肺癌
化疗
减毒增效
Non-small cell lung cancer
Chemotherapy
Synergism and attenuation
作者简介
通信作者:李秋华.
