摘要
非酒精性脂肪性肝病(NAFLD)是糖尿病、心脑血管疾病最常见危险因素,随着生活水平提高,NAFLD患病率急剧上升。微粒体甘油三酯转移蛋白(MTP)是肝脏脂质向外转运的关键酶,MTP启动子甲基化水平增加,是NAFLD肝脏脂质沉积重要因素。中医认为“脾气散精”,MTP脂质转运功能可能是“脾气散精”的表现形式之一,临床研究表明,健脾化湿法是治疗NAFLD的重要原则。本文通过综述相关文章,分析健脾化湿法可能通过调控MTP启动子甲基化水平,提高NAFLD肝脏MTP水平,促进肝脏脂质外流,减轻NAFLD脂质沉积,达到改善NAFLD的作用。
Nonalcoholic fatty liver disease (NAFLD) is the most common risk factor for diabetes mellitus and cerebrovascular and cardiovascular diseases. The prevalence of NAFLD is increasing rapidly with the improvement in living. Microsome triglyceride transfer protein (MTP) is a key enzyme for outward transport of liver lipids, and the increase in MTP promoter methylation is an important factor for liver lipid deposition in NAFLD. Traditional Chinese medicine believes that “spleen Qi transfers essence”, and the lipid transport function of MTP may be one of the manifestations of “spleen Qi transfers essence”. Clinical studies have shown that the spleen-strengthening and dampness-removing principle is of great importance in the treatment of NAFLD. By reviewing related articles, this article points out that the spleen-strengthening and dampness-removing therapy can improve NAFLD by regulating MTP promoter methylation, increasing the level of hepatic MTP, promoting the outflow of liver lipids, and alleviating lipid deposition.
作者
刘涛
徐秋玲
LIU Tao;XU Qiuling(Hainan Medical College, Haikou 571101, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第3期661-664,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81760795).
关键词
非酒精性脂肪性肝病
健脾化湿法
DNA甲基化
脂蛋白类
LDL
综述
non-alcoholic fatty liver disease
the principle of nourishing spleenand dispelling dampness
DNA methylation
lipoproteins, LDL
review
作者简介
刘涛(1977-),男,教授,博士,主要从事代谢综合征中医药治疗方面的研究;通信作者:徐秋玲,电子信箱:13215871860@163.com。
