摘要
目的研究补肾健脾止血方防治骨髓增生异常综合征(MDS)去甲基化治疗所致血小板减少的临床疗效。方法将39例MDS患者随机分为两组;对照组(18例)给予地西他滨治疗,治疗组(21例)给予地西他滨和补肾健脾止血方治疗。15天后,观察两组出血情况、血小板指标和血清IL-11水平变化。结果 1治疗组出血率为42.86%,对照组为66.67%;治疗组出血发生率低于对照组(P<0.05)。2治疗后两组血小板计数、血小板分布宽度、血小板压积均较治疗前增加(P<0.05),平均血小板体积较治疗前降低(P<0.05);治疗组血小板计数和血小板分布宽度大于对照组(P<0.05)。3两组治疗前后及组间血清IL-11水平无统计学差异(P>0.05)。结论补肾健脾止血方可防治MDS去甲基化治疗所致血小板减少,减少出血发生。
Objective To study the clinical effects of ＂ Bushen Jianpi Zhixue Decoction＂ in the prevention of thrembocytopenia after demethylation of myelodysplastic syndrome. Methods Thirty-nine subjects were randomized into two groups： control group in which 18 cases were treated with Decitabine Injection, and treatment group in which 21 cases were treated with Decitabine Injection and ＂Bushen Jianpi Zhixue Decoction＂. After 15 days, the bleeding condition, platelet indexes and the contents of serum IL- 11 were observed in both groups. Results （1）The bleeding rate was 42.86% in the treatment group and 66.67% in the control group, with lower rate in the treatment group than in the control group （P 〈 0.05 ）. （2）After treatment, the blood platelet count （PLT）, plateletcrit （PTC） and platelet volume distribution width （ PDW ） were increased （ P 〈 0.05 ） and the platelet volume （MPV） reduced （ P 〈 0.05 ） in both groups; there were significant differences in PLT and PDW between the two groups（ P 〈 0.05 ）. （3）The contents of serum IL- 11 were of no difference between before and after treatment in the two groups and between the two groups （ P 〉 0.05 ）. Conclusion ＂Bushen Jianpi Zhixue Decoction＂ can prevent thrombocytopenia after demethylation of myelodysplastic syndrome and reduce hemorrhage.
出处
《上海中医药杂志》
2015年第12期47-49,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市浦东新区社发局资助项目(PW2013A-1)
作者简介
[作者简介]贾新颜，女，在职博士生，主治医师，主要从事血液系统恶性疾病临床研究
[通讯作者]甘欣锦，博士，主任医师，硕士生导师。E-mail：ganxinjinl1@163．com
