摘要
目的探讨不同剂量的他汀类药物对急性脑梗死的临床治疗效果。方法 60例急性脑梗死患者,随机分为观察组与对照组,各30例。对照组采用小剂量阿托伐他汀(20 mg/次, 1次/d)进行治疗,观察组采用大剂量阿托伐他汀(40 mg/次, 1次/d)进行治疗,观察比较两组患者的美国国立卫生研究院脑卒中量表评分(NIHSS)、血脂指标、血清超敏C反应蛋白(hs-CRP)改善程度。结果治疗后,两组NIHSS评分均明显降低,且观察组(3.12±1.23)分明显低于对照组的(4.85±1.14)分,差异具有统计学意义(P<0.05)。治疗后,与对照组患者比较,观察组的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)显著下降,高密度脂蛋白胆固醇(HDL-C)显著升高,差异具有统计学意义(P<0.05)。治疗后,两组血清hs-CRP水平均明显降低,且观察组(3.41±2.04)mg/L明显低于对照组的(4.66±1.83)mg/L,差异具有统计学意义(P<0.05)。结论对急性脑梗死患者采用大剂量阿托伐他汀进行治疗,能够有效改善患者的神经功能,调节患者的血脂水平,进而提高患者的生活质量,值得临床推广。
Objective To investigate the clinical therapeutic effect of different doses of statins on acute cerebral infarction.Methods A total of 60 patients with acute cerebral infarction were randomly divided into observation group and control group,30 cases in each group.The control group was treated with 20 mg low dose Atorvastatin once a day.The observation group was treated with 40 mg high dose Atorvastatin once a day.The improvement of national institutes of health stroke scale(NIHSS),blood lipid indexes and serum high sensitivity C reactive protein(hs-CRP)between the two groups were observed and compared.Results After treatment,the NIHSS scores of the two groups were significantly reduced,the NIHSS score of the observation group was(3.12±1.23)scores,which was significantly lower than(4.85±1.14)scores,the differences were statistically significant(P<0.05).After treatment,compared with the control group,the triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)were decreased significantly in the observation group,the high density lipoprotein cholesterol(HDL-C)was increased significantly,the differences were statistically significant(P<0.05).After treatment,the levels of serum hs-CRP in the two groups were significantly decreased,and the level of serum hs-CRP in the observation group was(3.41±2.04)mg/L,which was significantly lower than(4.66±1.83)mg/L in the control group,the differences were statistically significant(P<0.05).Conclusion The application of high dose Atorvastatin in the treatment of acute cerebral infarction patients can effectively improve the neurological function of patients,regulate the levels of blood lipids,thereby improving the quality of life of patients,is worthy of clinical promotion.
作者
张雨时
ZHANG Yu-shi(Shenyang 242 Hospital,Shenyang 110034,China)
出处
《中国现代药物应用》
2018年第20期62-64,共3页
Chinese Journal of Modern Drug Application
关键词
不同剂量
阿托伐他汀
急性脑梗死
血脂水平
Different doses
Atorvastatin
Acute cerebral infarction
Blood lipid level
