摘要
目的探讨急性脑梗死患者采取阿替普酶溶栓治疗的效果及安全性。方法抽取2014年4月-2017年4月收治的急性脑梗死患者60例进行研究,入组对象有完整资料,家属签署知情同意书愿意配合研究,根据随机数表法分为两组,各30例,对照组按照常规方案治疗,研究组则采取阿替普酶溶栓治疗。评价两组患者临床效果,记录不良反应,测评治疗前后NIHSS评分,采取统计学分析。结果研究组患者总有效率显著高于对照组(P<0.05);两组患者治疗前NIHSS评分无差异(P>0.05),治疗后均有改善(P<0.05),但研究组显著优于对照组(P<0.05);两组不良反应发生率比较无差异(P>0.05)。结论急性脑梗死患者采取阿替普酶溶栓治疗,相比常规治疗可以提高疗效,改善脑卒中量表评分,且安全性高,值得借鉴。
Objective To investigate the effect and safetyusing thalidomide thrombolytic therapy in acute cerebral infarction patients.Methods We select 60 patients with acute cerebral infarction in this study,who were admitted in our hospital from April,2014 to April,2017.We have complete information about all the patients and got permission from the family members of patients with signed informed consent form.According to the random number table method,we divided it into 2 groups with 30 cases in each group.The comparison group adopted the conventional program of treatment,while the study group took alteplase thrombolytic therapy.We evaluated the clinical effects of the two groups,recorded adverse reactions,evaluated the NIHSS scores before and after treatment,and adopted the statistical analysis.Results The efficiency of the study group was significantly higher than that of the comparison group（ P〈0.05）; the NIHSS between the two groups had no significant difference before treatment（ P〈0.05）,but was improved after the treatment（ P〈0.05） and the NIHSS of the study group was obviously better than that of the comparison group; there was no significant difference in the incidence of adverse reactions between the two groups（ P〈0.05）.Conclusions Using alteplase thrombolytic therapy in acute cerebral infarction patients,compared with conventional treatment,can improve the efficacy and the stroke scale score with high safety,which is worth learning.
出处
《航空航天医学杂志》
2017年第11期1300-1302,共3页
Journal of Aerospace medicine
关键词
急性脑梗死
阿替普酶
溶栓
用药效果
acute cerebral infarction
alteplase
thrombolysis
therapy effect
