摘要
目的评估冠心病患者二级预防药物依从性,观察焦虑和抑郁对冠心病患者用药依从性的影响。方法选择2015年6月至2016年8月就诊于大连大学附属中山医院的急性冠脉综合征患者共340例,分别应用宗式焦虑自评量表(SAS)和宗式抑郁自评量表(SDS)进行评分,根据评分分为单纯冠心病组、冠心病合并焦虑组、冠心病合并抑郁组。检测冠心病合并焦虑或抑郁发生率;观察各组冠心病二级预防各种药物依从性。结果 (1)冠心病患者中,焦虑的发病率为36.9%,抑郁的发病率为39.1%;所有患者冠心病二级预防用药依从性:阿司匹林肠溶片为64.3%、他汀类药物为67.5%、血管紧张素转换酶抑制剂(ACEI)/血管紧张素Ⅱ受体拮抗剂(ARB)为52.8%、β受体阻滞剂为47.4%。(2)单纯冠心病组上述用药依从性分别为:73.1%、76.0%、61.4%、57.3%;冠心病合并抑郁组上述用药依从性:61.8%、62.9%、48.3%、43.8%,与单纯冠心病组相比较,用药依从性明显降低,且差异有统计学意义(P<0.05)。冠心病合并焦虑组上述用药依从性:62.7%、64.9%、48.7%、45.6%,与单纯冠心病组相比较,用药依从性有降低趋势,但无统计学差异(P>0.05)。结论抑郁降低冠心病患者二级预防用药的依从性。
Objective To analyze the current status of secondary prevention medication compliance,detect the effect of anxiety and depression on medication compliance prevention of patients with coronary heart disease(CHD).Methods A total of 340 patients diagnosed with acute coronary syndrome were selected in the center of Dalian university affiliated Zhongshan hospital from June 2015 to August 2016.An investigation on the medication compliance in secondary prevention of coronary heart disease,also the grading of Zung self-rating anxiety scale(SAS)and Zung self-rating depression scale(SDS)were evaluated on all of the patients.Results(1)The prevalence of anxiety and depression in CHD patients were 36.9%and 39.1%,respectively.Total medication compliance in secondary prevention for the CHD patients were 64.3%for aspirin,67.5%for atorvastatin/rosuvastatin,52.8%for irbesartan/losartan/Perindopril,and 47.4%for Metoprolol/bisoprolol,respectively.(2)The medication compliance in CHD without anxiety and depression were 73.1%,76.0%,61.4%,and 57.3%,respectively.The medication compliance in CHD with depression were 61.8%,62.9%,48.3%,and 43.8%,respectively.Compared to simple CHD,the medication compliance in CHD with depression were significantly decreased(P<0.05).The medication compliance in CHD with anxiety were 62.7%,64.9%,48.7%,and 45.6%,respectively.Compared to simple CHD,the medication compliance in CHD with anxiety tended to be lower(P>0.05).Conclusion Depression can affect the medication compliance in secondary prevention of patient with CHD.
作者
陈国亮
王丽丹
杨磊
张曙影
CHEN Guoliang;WANG Lidan;YANG Lei;ZHANG Shuying(Department of Cardiology,Zunyi Medical University,Zunyi 563000,China;Department of Cardiac Surgery,Affiliated Zhongshan Hospital of Dalian University,Dalian 116011,China;Department of Cardiology,the Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China;Department of Cardiology,Affiliated Zhongshan Hospital of Dalian University,Dalian 116011,China)
出处
《大连医科大学学报》
CAS
2018年第2期138-141,146,共5页
Journal of Dalian Medical University
关键词
冠心病
药物治疗
焦虑
抑郁
依从性
coronary heart disease
secondary prevention
anxiety
depression
medication compliance
作者简介
第一作者简介:陈国亮(1977-),男,主治医师。E-mail:12378982@qq.com;通信作者:张曙影,教授。E-mail:acezhangsy1868@163.com
