摘要
目的本文分析凝血指标、病种、年龄、性别等多因素对脑卒中和神经退行性病变高凝状态的相关性影响。方法纳入我院收治的脑出血、脑梗死、帕金森病和帕金森综合征共1103例患者的临床资料。采用免疫比浊法测定血浆部分凝血活酶时间(a PTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fbg)、D二聚体(D-D)、抗凝血酶(AT)以及纤维蛋白降解产物(FDP)等常规凝血指标。血常规采用五分类血细胞仪检测。结果①全部病例D-D均高于对照组;②大于60岁以上老年患者血浆D-D均明显增高;③60岁以上老年女性D-D水平高于同年龄男性D-D患者;④脑出血组D-D和FDP同步异常增高;⑤神经退行性病变患者存在D-D异常。结论脑卒中和神经退行性病D-D明显增高,60岁以上血浆D-D水平明显高于60岁以下者,帕金森帕病和帕金森综合征病以男性多见,且伴有血液高凝状态。
Objective positive rate and other factors effect on the correlation of hypercoagulability in stroke and neurodegenerative diseases.Methods 1103 cases of cerebral hemorrhage,cerebral infarction,Parkinson’s disease and Parkinsonism were include.General clinical data were collected,and routine coagulation indexs such as aPTT,PT,TT,Fbg,D-D,AT,FDP detected by turbidimetry,and peripheral blood cells were analyzed by five classification fully automatic hematology analyzer.Results①D-D of all cases was higher than the control group.②D-D increased significantly in the elderly patients over 60 years old.③The D-D level in the female(≥60)is higher than in the male patients at the same age.④Abnormal synchronous increase of D-D and FDP in cerebral hemorrhage group.Conclusion D-D level of cerebrovascular disease and neurodegenerative disease was significantly high.The level of D-D above 60 years old was remarkable higher than that under 60 years old.Parkinson’s disease and Parkinsonism were more common in male patients.There was no statistical significance change in the routine indexes of coagulation.
作者
顾昊
刘卫国
杨文清
袁士婷
李继民
许利刚
GU Hao;LIU Wei-guo;YANG Wen-qing;YUAN Shi-tIng;LI Ji-min;XU Li-gang(Department of Neurology,Nanjing Brain Hospital,Nanjing,210029,China)
出处
《血栓与止血学》
2020年第3期372-376,共5页
Chinese Journal of Thrombosis and Hemostasis
关键词
脑卒中
帕金森病
帕金森综合征
多因素
高凝状态
Stroke
Parkinson’s disease
Parkinsonism
Multi-factor conditional
High coagulation state
作者简介
通讯作者:许利刚
