摘要
目的观察抗幽门螺杆菌(Hp)治疗存在Hp感染的冠心病心绞痛的疗效。方法将存在Hp感染的冠心病心绞痛患者110例按随机数字表法分为对照组及研究组,每组55例,两组均给予硝酸酯类、抗凝、调脂等治疗,研究组在此基础上给予抗Hp治疗,两周为1疗程,共治疗2个疗程。治疗前后检测两组患者的TG、纤维蛋白原(FIB)及超敏C反应蛋白(hs-CRP)水平;治疗结束1个月后比较两组患者的症状缓解率及Hp根除率,3个月后比较两组患者心血管不良事件发生率。结果研究组治疗结束1个月后TG、FIB、hs-CRP水平均低于对照组,症状缓解率及Hp根除率均高于对照组(均P<0.05),3个月后心血管不良事件发生率低于对照组(P<0.05)。结论存在Hp感染的对冠心病心绞痛患者予以抗Hp治疗,可提高疗效、降低血脂水平及心血管不良事件发生率。
Objective To observe the efficacy of anti-Helicobacter pylori(Hp)adjuvant therapy for angina pectoris and coronary heart disease(CHD)suffering Hp infection.Methods A total of 110 CHD patients with angina pectoris and Hp infection were divided into control group and study group according to the random number table method,with 55 cases in each group.Both groups were given nitrates therapy,anticoagulation therapy and blood lipid-lowering therapy,and the study group received anti-Hp treatment on the basis of the therapy above.The course of treatment was two weeks,and the treatment lasted for two courses in the two groups.The levels of TG,fibrinogen(FIB)and high-sensitivity C-reactive protein(hs-CRP)were detected in both groups before and after treatment.The symptom remission rate and the eradication rate of Hp were compared between the two groups after one month of treatment,and the incidence rates of cardiovascular adverse events were compared between the two groups after three months of treatment.Results After one month of treatment,the levels of TG,FIB and hs-CRP in the study group were lower than those in the control group,the symptom remission rate and the eradication rate of Hp in the study group were higher than those in the control group(all P<0.05),and the incidence rates of cardiovascular adverse events in the study group were lower than those in the control group(P<0.05).Conclusion For CHD patients with angina pectoris and Hp infection,the anti-Hp therapy can improve the efficacy,reduce the level of blood lipid and the incidence rates of cardiovascular adverse events.
作者
陈颖
CHEN Ying(Department of Internal Medicine,Anshan Tumor Hospital,Anshan 114000,China)
出处
《广西医学》
CAS
2018年第6期653-655,共3页
Guangxi Medical Journal
关键词
冠心病
心绞痛
抗幽门螺杆菌
辅助治疗
Coronary heart disease
Angina pectoris
Anti-Helicobacter pylori
Adjuvant treatment
作者简介
陈颖(1972~),女,大学本科,副主任医师,研究方向:循环内科相关疾病诊断与治疗。电子邮箱:ascheny@163.com
