摘要
人巨细胞病毒(HCMV)感染后大多数无明显的临床症状,但可终身潜伏,并在特定条件下被激活而感染。孕期发生的HCMV活动性感染会导致流产、死胎、出生缺陷等,造成严重的经济和社会负担。由于原发性和继发性HCMV感染均可导致新生儿先天性感染,而目前无有效方法可筛查孕期HCMV继发性感染。因此对新生儿进行全面的先天性HCMV筛查,以便及早干预从而减轻先天性HCMV感染后果。文章对HCMV实验室检测的方法作一综述,并且分析其用于新生儿筛查的可行性,以期为新生儿先天性HCMV筛查方法的选择提供依据。
Most of the human cytomegalovirus(HCMV)infection has no obvious clinical symptoms,but it can be latent for life and activated under specific conditions.HCMV active infection during pregnancy can lead to abortion,stillbirth,birthdefect and so on,which causes serious economic and social burdens.Both primary and secondary HCMV infection can lead to congenital infection of newborn,but there is still no effective method for the screening of HCMV secondary infection during pregnancy currently.Therefore,a comprehensive congenital HCMV screening for newborns is implemented for early intervention and thus reducing the consequences of congenital HCMV infection.In this paper,the methods of HCMV laboratory detection and its feasibility for neonatal screening are analyzed,in order to provide a basis for the selection of methods in neonatal congenital HCMV screening.
作者
王晗
李廷栋
郭小怡(综述)
葛胜祥(审校)
WANG Han;LI Tingdong;GUO Xiaoyi;GE Shengxiang(National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Public Health, Xiamen University,Xiamen 361002, Fujian,China)
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2018年第3期221-226,共6页
Journal of Clinical Pediatrics
基金
国家自然科学基金资助项目(No.81472015,31670927)
关键词
人巨细胞病毒
先天性感染
新生儿筛查
human cytomegalovirus
congenital infection
neonatal screening
