摘要
目的:探究自然流产患者巨细胞病毒感染与血清TNF-α、IL-1、IL-6的关系。方法:收集2017年1月至2019年1月在我院就诊的110例自然流产孕妇的临床资料(观察组)和取同期在我院体检的70例正常孕妇的临床资料(对照组),并根据外周血HCMV-IgM、HCMV-DNA、HCMV-mRNA的检测结果将观察组分为两个亚组,任意两项阳性则为HCMV活动性感染,故活动性感染患者26例,非活动性感染患者84例。比较观察组与对照组孕妇的HCMV-IgM、HCMV-DNA、HCMV-mRNA的阳性率,炎性细胞因子(TNF-α、IL-1、IL-6)水平,以及活动性感染组和非活动性感染组炎性细胞因子水平,并分析HCMV活动性感染与TNF-α、IL-1、IL-6的关系。结果:观察组HCMV-IgM、HCMV-DNA、HCMV-mRNA的阳性率分别为37.37%、16.36%、2364%,明显高于对照组的7.14%、4.29%、5.71%,差异均有统计学意义(P<0.05)。观察组血清TNF-α、IL-1、IL-6水平均明显高于对照组,差异有统计学意义(P<0.05)。活动性感染组血清TNF-α、IL-1、IL-6水平均明显高于非活动性感染组,差异有统计学意义(P<0.05),提示血清TNF-α、IL-1、IL-6水平与活动性感染有关,且水平越高,活动性感染的风险越高。结论:HCMV感染引起是导致自然流产的重要原因之一,并且HCMV感染与TNF-α、IL-1、IL-6水平有关,其水平越高,活动性感染的风险越高,可能均在流产的发生中发挥重要作用。
Objective:To explore the relationship between cytomegalovirus infection and serum TNF-alpha,IL-1 and IL-6 in patients with spontaneous abortion.Methods:The clinical data of 110 cases of spontaneous abortion pregnant women(observation group)and 70 cases of normal pregnant women(control group)were collected from January 2017 to January 2019.The observation group was divided into two subgroups according to the detection results of HCMV-IgM,HCMV-DNA and HCMV-RNA in peripheral blood,and either of them was positive.For HCMV active infection,26 cases were active infection and 84 cases were inactive infection.The positive rates of HCMV-IgM,HCMV-DNA and HCMV-RNA,the levels of inflammatory cytokines(TNF-a,IL-1,IL-6)and the levels of inflammatory cytokines in active infection group and inactive infection group were compared between the observation group and the control group.The relationship between HCMV active infection and TNF-a,IL-1,IL-6 was analyzed.Results:The positive rates of HCMV-IgM,HCMV-DNA and HCMV-RNA in the observation group were 37.37%,16.36%and 2364%respectively,which were significantly higher than those in the control group(7.14%,4.29%and 5.71%),the differences were statistically significant(P<0.05).The serum levels of TNF-alpha,IL-1 and IL-6 in active infection group were higher than those in inactive infection group,the differences were statistically significant(P<0.05),it is suggested that serum TNF-α,IL-1 and IL-6 levels are related to active infection,and the higher the level,the higher the risk of active infection.Conclusion:HCMV infection is one of the important causes of spontaneous abortion,and HCMV infection is related to the levels of TNF-α,IL-1 and IL-6.The higher the level,the higher the risk of active infection,may play an important role in the occurrence of abortion.
作者
郑春娇
吴智明
黄素静
贾利平
ZHENG Chunjiao;WU Zhiming;HUANG Sujing(The Second Affiliated Hospital of Hainan Medical College, Hainan Haikou 570100, China)
出处
《河北医学》
CAS
2020年第2期342-345,共4页
Hebei Medicine
基金
2018年度海南省卫生计生行业科研项目，(编号:1801032031A2004)
