摘要
目的:探讨丙泊酚麻醉对颅脑外伤患者氧化应激、神经功能及炎症因子水平的影响。方法:选取2014年12月~2017年1月在我院进行手术的颅脑外伤患者102例,随机分为对照组和观察组,每组51例。对照组给予七氟烷1%~2%吸入及瑞芬太尼0.1~0.2μg/kg/min、维库溴铵20~30μg/kg/h进行麻醉维持;观察组给予丙泊酚4~6mg/kg/h、瑞芬太尼0.1~0.2μg/kg/min及维库溴铵20~30μg/kg/h进行麻醉维持。之后对两组患者氧化应激、神经功能及炎症因子水平进行评估。结果:与治疗前相比,治疗后两组患者SOD及HO-1水平均显著升高,MDA水平显著降低,差异有统计学意义(P<0.05),且观察组SOD和HO-1水平显著高于对照组,MDA水平显著低于对照组,差异有统计学意义(P<0.05);与治疗前相比,治疗后两组患者NSE、GFAP及Tau水平均显著减低,且观察组显著低于对照组,差异有统计学意义(P<0.05);与治疗前相比,治疗后两组患者IL-6、TNF-α及CRP水平均显著降低,且观察组显著低于对照组,差异有统计学意义(P<0.05)。结论:丙泊酚麻醉能显著降低患者氧化应激损伤、抑制炎症反应、保护患者神经功能,效果显著优于七氟烷麻醉,值得临床进一步推广应用。
Objective:To investigate the effect of propofol anesthesia on oxidative stress,neurological function and inflammatory cytokines in patients with craniocerebral trauma.Methods:102patients with craniocerebral trauma who underwent surgery in our hospital from December2014to January2017were randomly divided into control group and observation group.The control group was given1-2%of sevoflurane and0.1-0.2μg/kg/min of remifentanil and20-30μg/kg/h of vecuronium were maintained.The observation group was given propofol4-6mg/kg/h,remifentanil0.1-0.2μg/kg/min and vecuronium20-30μg/kg/h for anesthesia maintenance.The levels of oxidative stress,neurological function,and inflammatory factors were assessed in both groups.Results:Compared with before treatment,the levels of SOD and HO-1in the two groups were significantly increased and the levels of MDA were significantly decreased(P<0.05),and the levels of SOD and HO-1in the observation group were significantly(P<0.05).The level of MDA was significantly lower than that of the control group(P<0.05).Compared with before treatment,the levels of NSE,GFAP and Tau were significantly decreased in the two groups after treatment,and the difference was statistically significant(P<0.05).Compared with before treatment,the levels of IL-6,TNF-αand CRP in the two groups were significantly lower than those in the control group(P<0.05).Conclusion:Propofol anesthesia can significantly reduce the oxidative stress injury,inhibit the inflammatory reaction and protect the neurological function of patients.The effect is better than that of isoflurane anesthesia,and it is worthy of clinical application.
作者
刘艳
夏洁
彭宗军
马玉凤
LIU Yan;XIA Jie;PENG Zong-jun;MA Yu-feng(Department of anesthesiology Sichuan Friendship Hospital, Sichuan, Chengdu 610066, China;Department of Neurosurgery, Sichuan Friendship Hospital, Sichuan, Chengdu 610066, China)
出处
《海南医学院学报》
CAS
2017年第24期3471-3474,共4页
Journal of Hainan Medical University
基金
四川省科技厅科研项目(017231)~~
关键词
丙泊酚
颅脑外伤
氧化应激
神经功能
炎症因子
propofol
craniocerebral trauma
oxidative stress
neurological function
inflammatory factor
作者简介
刘艳（1983-）， 女，本科，主治医师, E -mail：liuyan4983@163.com。
