摘要
为观察万古霉素鞘内或静脉注射联合美罗培南治疗继发术后颅内感染临床效果。本研究共收集万古霉素联合美罗培南治疗术后继发颅内感染的患者130例,其中以万古霉素按使用途径的不同分为鞘内注射组72例(观察组)与静脉途径组58例(对照组)。分析两组患者治疗七天后的临床总有效率及脑脊液中白细胞数量、葡萄糖含量、蛋白质含量以及多核细胞含量。结果显示,与对照组比较,观察组治疗7天后总有效率显著升高,且脑脊液中葡萄糖含量、蛋白质含量以及多核细胞含量均显著升高,而白细胞数量显著降低。因此万古霉素鞘内联合美罗培南治疗继发术后颅内感染临床效果更佳,值得临床推广应用。
To explore the clinical effect of intrathecal or intravenous injection of vancomycin combined with meropenem in the treatment of secondary post-operative intracranial infections.130 patients with secondary postoperative intracranial infection who were treated with vancomycin combined with meropenem were enrolled in this study.According to the administration method of vancomycin,these patients were divided into intrathecal injection group(72 cases,observation group)and intravenous group(58 cases,control group).The clinical total effective rate and the number of white blood cells,glucose content,protein content and polynuclear cell content in cerebrospinal fluid of the two groups were analyzed after 7 days of treatment.The results showed that compared to the control group,the clinical total effective rate was significant higher,and the contents of glucose,protein and polynuclear cells in cerebrospinal fluid of the observation group were higher,while the number of white blood cells was lower.Therefore,intrathecal vancomycin combined with meropenem is more effective in the treatment of secondary post-operative intracranial infections,which is worthy of clinical application.
作者
张恩俊
陈先海
ZHANG Enjun;CHEN Xianhai(Department of Internal Medicine,Yunnan Infectious Disease Specialist Hospital,Kunming 650301,Yunnan,China;Department of Neurosurgery,the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,Shannxi,China)
出处
《中南医学科学杂志》
CAS
2020年第2期172-174,200,共4页
Medical Science Journal of Central South China
关键词
万古霉素
鞘内
颅内感染
美罗培南
静脉注射
vancomycin
intrathecal
intracranial infection
meropenem
intravenous injection
作者简介
通信作者:陈先海,E-mail:haizi0827@163.com.
