摘要
目的比较葵酸氟哌啶醇与利培酮对社区精神分裂症患者维持治疗效果差异。方法选取2013年5月至2015年6月来我院精神病科治疗并确诊的首发精神分裂症患者120例，将所有患者随机分为观察组和对照组，2组患者的性别、年龄、病程等一般性资料差异无统计学意义(P>0.05)，观察组使用葵酸氟哌啶醇治疗，给药剂量约50~100mg/m，对照组使用利培酮(西安杨森制药有限公司)治疗，给药剂量约2~4mg/d。2组患者持续治疗8周以上，治疗期间对患者的各项指标进行详实记录。将治疗前后2组患者的临床效果以及不良反应进行比较。临良反应的评价情况是通过锥体外系反应量表(RSESE)和社会功能缺陷量表(SDSS)进行评价。结果观察组和对照组治疗前的阳性、阴性以及一般药理和总分等差异无统计学意义(P>0.05)，经过治疗后患者的阳性、阴性以及一般药理和总分显著性低于治疗前评分。治疗结束后，观察组总有效率为85％；对照组总有效率为81.7％，2组的治疗效果差异无统计学意义(P>0.05)。观察组的不良反应发生率为25％，对照组的不良反应发生率为23.3％，二者差异无统计学意义(P>0.05)。结论应用葵酸氟哌啶醇与利培酮对社区精神分裂症患者维持治疗的效果具有不良反应发生率低，临床效果较好，安全性高，值得在临床上进一步推广运用。
Objective:To compare the kwai acid haloperidol and risperidone for the treatment of schizophrenia patients in community to maintain effect difference.Methods:Randomly selected from May2013to June2015in our hospital psychiatric treatment and diagnosis of120cases of patients with first-episode schizophrenia,all patients were divided into observation group and control group,two groups of patients with gender,age,course of general data such as there was no significant(P>0.05),the observation group for dosing for kwai acid haloperidol,give the dose of about50-100mg/month,the control dosing for risperidone yeung sum pharmaceutical co.,LTD.(xi'an),give the dose about2~4mg/d,appeared in the process of two groups of patients in the treatment of sleep quality,can take into consideration the use of benzodiazepines drugs for adjuvant treatment,so as to relieve symptoms.Two groups of patients with continuous treatment more than eight weeks,during all the indexes of patients with detailed records.The two groups of patients before and after the treatment of clinical effects and adverse reaction were compared.Evaluation is a good response in the extrapyramidal reaction scale(RSESE)and social function defect scale(SDSS).Results:The observation group and control group before treatment of the masculine,feminine and general pharmacology and total score,there was no significant difference(P>005)after treatment in patients with positive,negative and general pharmacology and total score significantly lower than the score before treatment.After treatment,the cured patients in observation group,31cases,15cases of patients were markedly improved,5patients with valid,invalid9cases of patients,the total effective rate was85%;,27patients with the control group recovered patients19cases were markedly effective,3patients with valid,invalid patients in11cases,the total effective rate was81.7%,the therapeutic effect of two groups there was no significant difference(P>0.05).Observation group the incidence of adverse reactions was25%,the control group is23.3%,what is happening the adverse reaction of no statistically significant difference between them(P>0.05).Conclusion:The application of aoi acid haloperidol and risperidone on schizophrenia patients in community to maintain the effect of the treatment with a low incidence of adverse reactions,clinical effect is good,high safety,is worth popularizing in further clinical application.
出处
《世界中医药》
CAS
2017年第A01期59-60,共2页
World Chinese Medicine
关键词
葵酸氟哌啶醇
利培酮
精神分裂症
临床效果
Haloperidol kwai acid
Risperidone. Schizophrenia
Clinical effect
