摘要
目的:探讨P16、P63和Ki67在宫颈上皮内瘤变及宫颈鳞癌中的表达及临床意义。方法:15例正常宫颈上皮、56例宫颈上皮内瘤变及23例宫颈鳞癌均做免疫组织化学染色,比较不同类型病变P16、P63和Ki67的表达情况。结果:P16、P63和Ki67在上皮内瘤变和鳞癌的表达均明显高于正常宫颈上皮(均P<0.05)。结论:P16、P63和Ki67与宫颈上皮内瘤变和鳞癌的发生发展密切相关,可作为评价宫颈上皮内瘤变和宫颈鳞癌程度的指标。
Objective:To explore the expression and clinical significance of P16,P63 and Ki67 in cervical intraepithelialneoplasia and cervical squamous cell carcinoma.Methods:15 cases of normal cervical epithelium,56 cases of cervicalintraepithelial neoplasia and 23 cases of cervical squamous cell carcinoma were given immunohistochemistry.The expressionconditions of P16,P63 and Ki67 of different types of lesions were compared.Results:The expressions of P16, P63 and Ki67 ofintraepithelial neoplasia and squamous cell carcinoma were significantly higher than those of the normal cervical epithelium(Pall<0.05).Conclusion:P16,P63 and Ki67 are closely related to the occurrence and development of cervical intraepithelialneoplasia and squamous cell carcinoma,which can be used as indexes to evaluate the degree of cervical intraepithelial neoplasiaand cervical squamous cell carcinoma.
作者
张明伟
孙际燕
孙式荣
Zhang Mingwei;Sun Jiyan;Sun Shirong(Laicheng District People's Hospital of Laiwu City,Shandong Province 271100)
出处
《中国社区医师》
2016年第7期129-130,共2页
Chinese Community Doctors
