摘要
目的分析中国（未包括中国香港特别行政区、澳门特别行政区和台湾）2016年疑似预防接种异常反应（Adverse events following immunization,AEFI）的发生特征。方法通过中国免疫规划信息管理系统收集2016年发生的AEFI个案数据和疫苗接种数据,采用描述流行病学方法进行数据分析。结果 2016年中国共报告185 583例AEFI个案,男、女性别报告数之比为1.27∶1;≤1岁儿童占74.01%;一般反应占92.45%、异常反应占6.18%。68.51%的不良反应发生在接种后0d。AEFI总报告发生率为39.01/10万剂;一般反应、异常反应、严重异常反应报告发生率分别为36.06/10万剂、2.41/10万剂、0.16/10万剂。报告例数居前5位的异常反应为过敏性皮疹9 569例（2.01/10万剂）、血管性水肿347例（0.07/10万剂）、卡介苗淋巴结炎260例（1.50/10万剂）、热性惊厥236例（0.05/10万剂）、卡介苗局部脓肿123例（0.71/10万剂）。结论 2016年中国AEFI以一般反应为主,严重异常反应报告发生率极低。
Objective To determine characteristics of adverse events following immunization（ AEFIs） in China（ excluding Chinese Hong Kong Special Administrative Region,Macao Special Administrative Region,and Taiwan） in 2016. Methods AEFI case data and vaccine doses-administered data from2016 were obtained through the National Immunization Program Information Management System for descriptive epidemiological analyses. Results In total,185 583 AEFI cases were reported; the male to female ratio was 1. 27∶ 1; 74. 01% were among children less than 2 years old; 92. 45% were common vaccine reactions; 6. 18% were rare vaccine reactions; and 68. 51% of reactions occurred within 1 day of vaccination. The total estimated AEFI rate was 39. 01 per 100 000 doses. By severity,36. 06,2. 41,and 0. 16 AEFI cases per 100 000 doses were for common vaccine reactions,rare vaccine reactions,and serious rare vaccine reactions,respectively. The top five rare vaccine reactions were anaphylactic rash（ 9 569 cases,2. 01 per 100 000 doses）,angioedema（ 347 cases,0. 07 per 100 000 doses）,lymphadenitis by Bacilli Calmette-Guérin（ BCG） vaccine（ 260 cases,1. 50 per 100 000 doses）, febrile convulsion（ 236 cases,0. 05 per 100 000 doses）,and local abscess by BCG vaccine（ 123 cases,0. 71 per 100 000 doses）. Conclusions Most AEFIs were common vaccine reactions in China in 2016,with an extremely low rate of serious vaccine reactions.
作者
许涤沙
李克莉
武文娣
叶家楷
吉赛赛
郑景山
崔健
曹玲生
肖奇友
Xu Disha;Li Keli;Wu Wendi;Ye Jia- kai;Ji Saisai;Zheng Jingshan;Cui Jian;Cao Lingsheng;Xiao Qiyou(Department of National Immuniza- tion Program, Chinese Center for Disease Control and Prevention, Beifing 100050, China)
出处
《中国疫苗和免疫》
北大核心
2018年第3期299-309,322,共12页
Chinese Journal of Vaccines and Immunization
基金
中国CDC公共卫生应急反应机制的运行(131031001000150001)
关键词
疑似预防接种异常反应
监测
Adverse events following immunization
Surveillance
作者简介
通信作者：李克莉，Email：likl@chinacdc．cn
