摘要
炎性痛作为常见的临床病症之一,严重影响了患者的工作和日常生活,目前其发病机制尚未明确。已有研究表明,P2X3受体参与急、慢性炎性痛的病理过程。文章围绕炎性痛中P2X3受体所起的作用及其与TRPV1受体、炎症介质和Epac-PKC信号传导通路的关系等方面进行综述,为炎性痛的研究和治疗提供新思路。
Inflammatory Pain is one of the most common clinical symptom with unclear pathogenesis,which causes difficulty in patien＇s work and daily life. Previous studies have shown that P2 X3 receptor participates in the pathological process of acute and chronic inflammatory pain. This paper focuses on the functions of P2 X3 receptor in inflammatory pain and its relationship with TRPV1 receptor,inflammatory mediator and Epac-PKC signal transduction pathway,thereby provides a new thought for research and treatment of this disease.
作者
项璇儿
杜俊英
方剑乔
XIANG Xuan-er;DU Jun-ying reviewing;FANG Jian-qiao checking(The Third Clinical Medical College, Zhefiang Chinese Medicine University ,Hangzhou 310053 ,Zhefiang, China)
出处
《医学研究生学报》
CAS
北大核心
2018年第6期649-652,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金(81473772)
浙江省医药卫生重大科技计划(WKJ-ZJ-1419)
浙江省一流学科(中医学)资助(浙政办函[2016]6号)
作者简介
医学博士研究生;通信作者：方剑乔，E—mail：fangjianqia07532@163．com
