摘要
神经病理性疼痛是临床疼痛治疗的难点之一,由于其难治性,极大降低了患者的生活质量。因此,药物治疗神经病理性疼痛成为众多临床学者和患者所共同关注的问题。目前,抗抑郁药和抗癫痫药是药理学上研究最广泛的两种药物,它们代表了现今治疗神经病理性疼痛的一线药物。随着新一代的抗抑郁药和第二代抗癫痫药的研发,使得药物治疗神经病理性疼痛有了新的契机。本文就此两种药物的作用机制和治疗现状进行综述,旨在为神经病理性疼痛的临床治疗提供理论参考。
Refractory neuropathic pain can be devastating to a patient＇s quality of life and the management of neuropathic pain remains challenging. So the pharmacotherapy for neuropathic pain is the primary focus of pain management for many clinical researchers and patients with painful neuropathy. Up till now, antidepressants and anticonvulsants are two pharmacological classes most widely studied and represent first-line agents in the management of neuropathic pain. The development of newer classes of antidepres-sants and second-generation anticonvulsants has created unprecedented opportunities for the treatment of neuropathic pain.＇This paper reviews the mechanisms of action and present clinical treatment situation of antidepressants and anticonvulsants in order to provide reference of the pharmacotherapy for neuropathic pain.
出处
《实用疼痛学杂志》
2008年第1期53-56,共4页
Pain Clinic Journal
关键词
抗抑郁药
抗癫痫药
神经病理性疼痛
疼痛
机制
药物疗法
Antidepressive Agents
Antiepileptic Agents
Neuropathie Pain
Pain
Mech- anism
Drug Therapy
