摘要
目的系统评价创伤性脊髓损伤(spinal cord injury,SCI)在中国的流行病学特征和疾病经济负担。方法计算机检索PubMed、EMbase、WanFang Data、VIP和CNKI数据库,搜集有关中国SCI流行病学和疾病经济负担的研究,检索时限均从1978年1月1日至2017年8月30日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行合并分析。结果共纳入32篇文献。Meta分析结果显示:我国SCI年患病率为37人次/100万[95%CI(21,53)],平均年龄范围34.7~54.4岁,男性高于女性。汽车碰撞和高空坠落是SCI的主要原因。SCI严重程度从A^E级(ASIA分级)不等,以A级为主,E级比例最低。结论当前证据显示,我国SCI发病率较高,具有较高的社会和医疗负担,SCI主要由汽车碰撞和高空坠落引起。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。
Objective To systematically review the epidemiological characteristics and economic burden of traumatic spinal cord injury （SCI） in China. Methods PubMed, EMbase, WanFang Data, VIP and CNKI databases were electronically searched to collect studies of the epidemiological characteristics and economic burden of SCI in China from January 1st, 1978 to August 30th, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using Stata 12.0 software. Results A total of 32 studies were included. The results of meta-analysis showed that： the prevalence of SCI in China was 37 persons per million per year （95%CI 21 to 53）, with the average age ranged from 34.7 to 54.4 years. Men had a higher risk of SC1 than Women. Motor vehicle collisions （MVCs） and falls were the two main causes of SCI. The neurological injury levels were varied, ASIA grade A was the most common and grade E was the least. Conclusion Current evidence shows that there is a high prevalence of SCI in China with heavy social and medical burden. The main reason of SCI is motor vehicle collisions and falls. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify above conclusion.
出处
《中国循证医学杂志》
CSCD
北大核心
2018年第2期143-150,共8页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金项目(编号：81501933)
浙江省卫生厅项目(编号：2018KY129)
温州市领军型人才创新创业项目(编号：RX20l6004)
温州市科技局项目(编号：Y20170389)
关键词
脊髓损伤
流行病学
经济负担
系统评价
Spinal cord injury
Epidemiology
Economic burden
Systematic review
作者简介
通信作者：吴爱悯，Email：aiminwu@wmu．edu．cn
