摘要
穿山龙属于薯蓣科植物,广泛分布于我国的华北、东北、青海等地区,其根茎是一种重要的中药材,在我国具有几千年的应用历史。据中医学记载,该药材具有止咳化痰、祛风止痛、舒筋活血等功效。现代研究表明,该药材的主要活性成分为皂苷,具有抗肿瘤、抗炎、降血脂、抑菌和抗病毒等作用。鉴于其诸多的生物学活性及药理作用,针对其开发和应用具有良好的前景。该文对穿山龙皂苷的药理活性、治疗作用及机制的研究现状加以总结,为进一步研发穿山龙皂苷提供理论基础。
Dioscorea nipponica, a famous traditional Chinese medicine, belongs to the Dioscoreaceae family and has been widely distributed in the north, northeast and Qinghai regions of China. With its root and rhizome as an important herb material, it has been applied in China for several thousand years. Traditional Chinese medicine reported that this plant had been used for relieving cough and asthma, eliminating rheumatic aches, alleviating pain and improving blood circulation. Modern pharmacology studies have confirmed that saponins, the major active compounds in this herb, have shown various pharmacological actions including anti-tumor, anti-inflammatory,lipid-lowering, anti-fungal and anti-virus activities. Therefore, the studies on saponins from D. nipponica are valuable and promising. In this present research, the pharmacological actions, therapeutic effects and mechanism of saponins from D. nipponica were summarized in order to provide the theoretical basis for the further research.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第24期4694-4699,共6页
China Journal of Chinese Materia Medica
关键词
穿山龙皂苷
药理活性
分子机制
saponins from Dioscorea nipponica
pharmacological activity
mechanism
作者简介
于浩，药师，E—mail：science_17@163．com;[通信作者]杜建玲，教授，博士生导师，主要从事糖尿病大血管并发症的基础与临床研究，Tel：（0411）83635963，E-mail：dujianling63@163．com
