摘要
目的观察合募配穴灸法治疗脾胃虚寒型慢性萎缩性胃炎(CAG)患者的临床疗效及对血清胃蛋白酶原及胃泌素的影响。方法将符合诊断及纳入标准的63例脾胃虚寒型萎缩性胃炎患者,按照随机数字表法分为对照组(31例)和治疗组(32例),对照组给予胃复春片治疗,治疗组给予合募配穴艾灸法治疗,两组疗程均为12星期。分别评价两组临床疗效、中医症状积分及血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及胃泌素(G17)的变化。结果治疗组治疗后总有效率为93.8%,明显优于对照组(P<0.05);两组治疗后及随访时中医症状积分显著降低(P<0.01),且治疗组明显优于对照组(P<0.01);治疗组治疗后PGⅠ、PGR及G-17水平显著增高(P<0.01),PGⅡ较治疗前降低(P<0.05);对照组治疗后PGⅠ、PGR及G-17水平明显增高(P<0.05),两组治疗后PGⅠ、PGR及G-17组间比较,治疗组明显优于对照组(P<0.01),两组治疗后PGⅡ组间比较差异具有统计学意义(P<0.05),治疗组随访HP阳性率为3.1%,明显低于对照组(P<0.05)。结论合募配穴灸法能显著改善CAG患者临床症状,增加HP的清除率及降低复发率,其作用机制可能是通过上调PGⅠ、PGR及G-17和下调PGⅡ水平实现的。
Objective To observe the clinical efficacy of moxibustion at He-Sea plus Front-Mu points in treating chronic atrophic gastritis （CAG） due to deficient cold in spleen-stomach, and its effect on serum pepsinogen （PG） and gastrin. Method Sixty-three eligible patients with CAG due to deficient cold in spleen-stomach were divided into a control group （31 cases） and a treatment group （32 cases） by using random number table. The control group was intervened by Wei Fu Chun tablets, while the treatment group received moxibustion at He-Sea plus Front-Mu points, 12 weeks as a treatment course. Clinical efficacy, symptoms score of traditional Chinese medicine （TCM）, serum PG I, PG II and gastrin levels were evaluated. Result The total effective rate was 93.8% in the treatment group, significantly better than that in the control group （P〈0.05）; the TCM symptoms scores dropped significantly in both groups after the treatment and in the follow-up study （P〈0.01）, and the treatment group was markedly superior to the control group （P〈0.01）; the levels of PG I, PG I/II ratio （PGR） and gastrin-17 （G-17） increased significantly in the treatment group after the intervention （P〈0.01）, and PG II dropped significantly （P〈0.05）; after the treatment, the levels of PG I, PGR and G-17 increased significantly in the control group （P〈0.05）; after the intervention, the treatment group was significantly better than the control group in comparing the levels of PG I, PGR and G-17 （P〈 0.01）, and there was a significant difference in comparing the level of PG II between the two groups after the intervention （/＇〈0.05）. The follow-up showed that the HP positive rate was 3.1% in the treatment group, significantly lower than that in the control group （P〈0.05）. Conclusion Moxibustion at He-Sea plus Front-Mu points can significantly improve CAG symptoms, enhance HT clearance and lower the relapse; its action mechanism is possibly through up-regulating PG I, PGR and G-17 and down-regulating PG II.
作者
张迪
袁星星
王炳予
张雅丽
ZHANG Dil;YUAN Xing-xing;WANG Bing-yul;ZHANG Ya-li(Nangang Branch of Heilongiiang Academy of Chinese Medical Sciences,Harbin 150001,China;Institute of Senile Constipation, Heilong/iang Academy of Chinese Medical Sciences,Harbin 150001,China)
出处
《上海针灸杂志》
2017年第12期1401-1405,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
黑龙江省科技厅科技攻关项目(GC12C110)
关键词
温灸器灸
胃炎
萎缩性
配穴法
胃蛋白酶原
胃泌素类
穴
中脘
穴
足三里
灸法
Instrument-based mild moxibustion
Gastritis, Atrophic
Points grouping method
Pepsinogen
Gastrin
Point, Zhongwan （CV 12）
Point, Zusanli （ST36）
Moxibustion
作者简介
张迪（1975-），女，副主任护师，Email：m15204619036@163.com;张雅丽（1961-），女，主任医师，博士，硕士生导师，Email：zhangyl-2013@sina．com
