摘要
目的了解上海市社区老年人高尿酸血症(HUA)发病率及其影响因素,为HUA的社区预防和干预提供实证依据。方法采用随机整群抽样方法抽取上海市泥城社区2014年体检血尿酸正常的3 455名≥65岁常住居民作为随访队列进行为期1年的随访,于2015年4—6月对其进行问卷调查、体格检查和实验室检测,分析其HUA发病率及影响因素。结果上海市3 455名社区老年人中,完成随访者3 248人,随访率为94.01%;3 248名随访老年人中,HUA新发病例165例,发病率为5.08%;多因素非条件logistic回归分析结果显示,饮酒、摄入海鲜≥3次/周、体质指数≥24.0 kg/m^2、高血压、甘油三酯≥2.26 mmol/L、低密度脂蛋白胆固醇≥4.14 mmol/L和血肌酐>97μmol/L是上海市社区老年人HUA发病的危险因素,而参加体育锻炼和糖化血红蛋白≥6.5%是上海市社区老年人HUA发病的保护因素。结论上海市社区老年人HUA发病率较高,体质指数、甘油三酯、低密度脂蛋白胆固醇、血肌酐、糖化血红蛋白、海鲜摄入频次及是否高血压、饮酒、参加体育锻炼是该社区老年人HUA发病的主要影响因素。
Objective To investigate the incidence and risk factors of hyperuricemia （HUA） among community elderly in Shanghai city and to provide evidences for the community prevention and intervention of HUA. Methods A total of 3 455 residents aged 65 years and above and free of hyperuricemia at a baseline examination in 2014 were recruited into a cohort study through random cluster sampling in Nicheng community of urban Shanghai. By the end of one year fol- low-up, a questionnaire survey, physical examination and laboratory tests were conducted among the participants between April and June 2015 to analyze the incidence and risk factors of HUA. Results For all the participants, 3 248 （94.01% ） completed the follow-up, of which, 165 （5. 08 % ） developed HUA. Multivariate logistic regression analyses revealed that alcohol consumption,intake of seafood ≥3 times/week, with body mass index（BMI） of ≥24.0 kg/m2, hypertension,triglycerides of t〉2. 26 mmol/L,low-density lipoprotein cholesterol of ≥4. 14 mmol/L, and serum creati- nine of 〉 97 μmol/L were risk factors of HUA. Whereas, regular physical exercise and with glycated hemoglobin of ≥ 6. 5% were protective factors of HUA. Conclusion The incidence of HUA were relatively high and was mainly influenced by BMI,triglycerides,low-density lipoprotein cholesterol,serum creatinine,glycated hemoglobin,frequency of seafood intake,hy- pertension,alcohol consumption and regular physical exercise among community elderly in urban Shanghai.
作者
刘胜峰
赖华娟
何纳
LIU Sheng-feng LAI Hua-juan HE Na(Nicheng Community Health Service Center, Shanghai 201306, China)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2017年第10期1445-1449,共5页
Chinese Journal of Public Health
基金
上海市浦东新区卫生和计划生育委员会科技发展专项基金资助(PW2015C-17)
作者简介
刘胜峰（1982-），男，安徽合肥人，主管技师，硕士，研究方向：实验室诊断、流行病学调查与公共卫生管理。
通讯作者：何纳，E-mail：nhe@shmu．edu．cn
