摘要
目的了解广东省粤东山区高尿酸血症的患病情况及及其相关影响因素。方法于2015年1—12月采用随机整群抽样法抽取粤东山区2 616人为调查对象,采用问卷调查法统计所有人员的一般情况,同时进行常规体检及相关生化指标检测。结果有效调查2 587人高尿酸血症的患病率为10.78%(279/2 587);随着年龄升高,男性患病率逐渐下降,女性患病率逐渐上升,但男性整体患病率12.41%(175/1 410),明显高于女性8.84%(104/1 177)(P<0.05),其中在<55岁表现尤为明显;男性血清尿酸平均水平明显高于女性(P<0.05)。多因素logistic回归分析显示男性(OR=1.253,P=0.027)、肥胖(OR=1.515,P=0.017)、肉类摄入(OR=2.256,P=0.019)、饮酒(OR=1.257,P=0.011)、高血脂(OR=2.256,P=0.021)、高血压(OR=1.657,P=0.015)、高胆固醇(OR=5.052,P=0.003)是影响高尿酸症的主要独立因素。结论粤东山区男性高尿酸血症患者多于女性,且饮酒、过量食肉、肥胖、血脂偏高、胆固醇偏高或高血压均会增加高尿酸血症的发生风险。
Objective To investigate the prevalence and influencing factors of hyperuricemia among adult residents in eastern mountain area of Guangdong province. Methods A total of 2 616 permanent residents aged 35 - 75 years were recruited with random cluster sampling from 12 administrative villages in eastern mountain area of Guangdong province. A questionnaire survey, physical examination, and related biochemical measurements were conducted among the residents from January through December 2015. Results The prevalence rate of hypemricemia was 10.78% among the 2 587 participants successfully completing all survey items;a significantly higher prevalence rate was observed among the male participants than among the female residents （ 12.41% [ 175/1 410 ] vs. 8. 84% [ 104/1 177 ], P 〈 0. 05 ） and the gender difference in the prevalence rate was much more obvious among the participants less than 55 years old;the prevalence rate decreased in the male participants but increased in the female participants with the increment of age. The average serum uric acid level of the males was significantly higher than that of the females （ P 〈 0. 05 ）. Multivariate logistic regression analysis showed that male gender （ odds ratio[ OR] = 1. 253, P = 0. 027 ）, obesity （ OR = 1. 515, P = 0. 017 ）, meat intake （ OR = 2. 256, P = 0. 019 ）, alcohol drinking （ OR = 1. 257, P =0. 011 ）, hypedipidemia （ OR = 2. 256, P = 0. 021 ）, hypertension （ OR = 1. 657, P = 0. 015 ）, and high cholesterol （ OR = 5. 052, P = 0. 003 ） were major independent influence factors of hyperuricemia, but hyperglycemiar （ OR = 2. 312, P = 0. 063 ） was a non-independent factor. Conclu- sion The prevalence of hypernricemia is higher among male adult residents than among the female residents and main risk factors of hyperuricemia are alcohol drinking, high meat consumption, obesity, high blood fat and cholesterol, and hypertension among the adult residents in eastern mountain area of Guangdong province.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2017年第2期317-320,共4页
Chinese Journal of Public Health
关键词
高尿酸血症
粤东山区
患病率
影响因素
hyperuricemia
mountain area of eastern Guangdong
prevalence rate
influencing factor
作者简介
谢悦胜（1981-），男，广东梅州人，医师，硕士在读，主要从事痛风和高尿酸血症方面研究。
