摘要
目的探讨帕罗西汀对老年食管癌根治术后抑郁症情绪免疫功能的影响。方法将84例食管癌根治术后伴发抑郁症的老年患者随机分为观察组与对照组,各42例。两组术后均予以常规治疗,观察组加用帕罗西汀治疗8周。比较两组治疗前后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分,测定两组治疗前后免疫指标。结果治疗8周后,两组HAMD、HAMA评分均较治疗前显著降低,且观察组显著低于对照组(P<0.05);两组CD_8^+均明显降低,CD_4^+、CD_4^+/CD_8^+、IgA、IgG、IgM均显著提高,且观察组的改善幅度显著优于对照组(P<0.05)。结论帕罗西汀治疗老年食管癌根治术后抑郁症能够有效缓解焦虑、抑郁症状,改善体液和细胞免疫功能。
Objective To investigate the effect of paroxetine on elderly patients with depression after esophageal cancer radical surgery and its influence on their immune function. Methods Eighty-four elderly patients with depression after esophageal cancer radical surgery were randomly divided into observation group and control group,each with 42 cases. Both groups received routine treatment,the observation group was treated with paroxetine for 8 weeks. The HAMD,HAMA scores and immune function indexes of the two groups before and after treatment were measured and compared. Results After 8 weeks of treatment,the HAMD and HAMA scores were significantly decreased in both two groups,the scores of patients in observation group were significantly lower than those in the control group（P〈0.05）;After treatment,the levels of CD8＋ were significantly decreased,levels of D4＋,CD4＋/CD8＋,IgA,IgG,IgM were significantly increased in both two groups,while the improvements in observation group were significantly better than that in the control group（P〈0.05）. Conclusion Paroxetine can effectively alleviate the anxiety and depression symptoms on elderly patients with depression after esophageal cancer radical surgery and improve their humoral and cellular immune function.
作者
葛鹏
杨淑慧
周琪
孙菲
高金叶
姜涛
GE Peng YANG Shuhui ZHOU Qi et al(Second Affiliated Hospital, Xi＇ an Medical College, Xi＇an 710038, China)
出处
《国际精神病学杂志》
2017年第5期877-879,883,共4页
Journal Of International Psychiatry
关键词
食管癌根治术
抑郁症
帕罗西汀
免疫功能
Esophageal cancer radical surgery
Depression
Paroxetine
Immune function
作者简介
葛鹏（1977．12-），男，陕西泾阳人，硕士，副主任医师，研究方向：胸部微创、肿瘤学。
[通讯作者]姜涛（Email：jiangtaochest@163．com）。
