摘要
目的观察吉西他滨联合卡培他滨治疗转移性三阴乳腺癌(TNBC)的临床疗效。方法将2015年1月至2016年3月收治的90例转移性TNBC患者随机分为两组,各45例,对照组患者静脉滴注多西他赛注射液治疗,观察组患者联合吉西他滨与卡培他滨进行治疗,比较两组患者的临床疗效及毒性反应。结果观察组总有效率为60.00%,高于对照组的37.78%(P<0.05);毒性反应发生率为22.22%,低于对照组的42.22%(P<0.05)。结论吉西他滨联合卡培他滨治疗转移性TNBC的疗效确切,值得临床推广。
Objective To observe the clinical efficacy of gemcitabine combined with capecitabine in the treatment of metastatic triple-negative breast cancer（TNBC）.Methods Totally 90 patients with metastatic TNBC in our hospital from January 2015 to March 2016 were divided into two groups,45 cases in each group.The control group was treated with intravenous injection of docetaxel,and the observation group was treated with gemcitabine combined with capecitabine.The clinical efficacy and toxicity were compared between the two groups.Results The total effective rate of the observation group was 60.00%,which was significantly higher than 37.78% of the control group（P 〈 0.05）.The incidence rate of toxicity was 22.22%,which was significantly lower than 42.22% of the control group（P 〈 0.05）.Conclusion Gemcitabine combined with capecitabine in the treatment of metastatic TNBC is effective,it is worthy of clinical promotion.
作者
赵雪云
李远平
张英毅
祝琴
黄亮
张强
Zhao Xueyun Li Yuanping Zhang Yingyi Zhu Qin Huang Liang Zhang Qiang(Leshan People＇s Hospital, Leshan, Sichuan, China 614000)
出处
《中国药业》
CAS
2017年第15期29-31,共3页
China Pharmaceuticals
关键词
三阴乳腺癌
吉西他滨
卡培他滨
triple-negative breast cancer
gemcitabine
capecitabine
作者简介
赵雪云（1958-），男，硕士研究生，主治医师，研究方向为甲状腺、乳腺疾病的诊治，（电子信箱）1154491694@qq．com。
