摘要
目的探究五水头孢唑林钠+桃金娘油治疗儿童急性化脓性中耳炎的临床疗效及安全性。方法选取我院2014年1月~2016年1月收治120例确诊为急性化脓性中耳炎患儿,随机分成四组(各30例),分别采用五水头孢唑林钠加用桃金娘油、头孢唑林钠加用桃金娘油、五水头孢唑林钠、头孢唑林钠4组治疗。观察并记录4个组患儿临床疗效、临床症状消失时间及药物不良反应发生情况。结果4个组患儿间年龄、性别、平均病程均无明显差异。五水头孢唑林钠+桃金娘油治疗组临床疗效优于其他3个组(P均<0.05),头孢唑林钠+桃金娘油组与五水头孢唑林钠组两组比较无差异(P>0.05),且两组均优于头孢唑林钠组(P<0.05)。患儿症状(包括耳痛、听力下降、发热、鼓膜充血)消失时间,五水头孢唑林钠+桃金娘油组均短于另3个组(P均<0.05)。用药后发生不良反应,4个组间无统计学差异(P>0.05)。结论五水头孢唑林钠+桃金娘油治疗儿童急性化脓性中耳炎临床效果优于另3种用药方案,且不增加安全性风险。
OBJECTIVE To investigate the effectof Myrtol combined with Cefazolin Sodium Pentahydrate in the treatment of acute suppurative otitis media in children. METHODS Totally 120 cases of pediatric acute suppurative otitis media were selected in our hospital from January 2014 to January 2016 and randomly divided into four groups, treated with Myrtol combined with Cefazolin Sodium Pentahydrate, Myrtol combined with Cefazolin Sodium, Cefazolin Sodium Pentahydrate, or Cefazolin Sodium, respectively. The effect and adverse reactions of the 4 groups were studied and compared. RESULTS There was no significant differences in age, sex, and average course of disease among the four groups. In Myrtol combined with Cefazolin Sodium Pentahydrate group, the clinical efficacy is better than that of the other three groups （P〈 0.05）.There was no difference between Myrtol combined with Cefazolin Sodium group and the Cefazolin Sodium Pentahydrate group（P〉 0.05）, and both of them are better than cefazolin sodium group（P〈 0.05）. For the disappearance time of symptoms, including earache, hearing loss, fever and tympanic hyperaemia, Myrtol combined with Cefazolin Sodium Pentahydrate treatment was shorter than the other three groups （P〈 0.05）. There was no significant differences among the three groups（P〉 0.05）. CONCLUSION Myrtol combined with Cefazolin Pentahydrate Sodium treatment was superior to the other three protocols in clinical efficacy for children with acute suppurative otitis media, and does do not increase the risk of safety.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2017年第7期347-350,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
儿童
中耳炎
化脓性
临床方案
五水头孢唑林
钠
桃金娘油
头孢唑林钠
Child
Otitis Media, Suppurative
ClinicalProtocols
cefazolin sodium pentahydrate
myrtol
cefazolinsodium
作者简介
第一作者简介及通讯：丁小军，男，江苏人，医学硕士，副主任医师主要从事耳鼻咽喉科相关疾病诊治。Email：dingxiaojun78@21cn．com
