摘要
目的:通过探讨"消脂方"治疗湿热型非酒精性脂肪性肝病(NAFLD)的临床疗效,为其治疗提供参考。方法:选择2013年10月至2015年10月本院中医科、消化内科诊治的NAFLD患者共100例,采用随机数字表法随机分为对照组(45例)和观察组(55例)。观察组以清热利湿、疏肝健脾为治疗原则制定消脂方治疗方案,对照组给予益肝灵片治疗,治疗期间要求患者加强活动,并适当控制饮食。治疗3个月后,观察患者临床有效性指标和安全性评价指标。结果:观察组患者治疗总有效率为96.36%,显著高于对照组的80.00%(P<0.05)。治疗后,2组患者症状积分均较治疗前降低(P<0.05),且观察组中医症状积分显著低于对照组(P<0.05)。治疗后,2组患者TC、TG均较治疗前显著降低(P<0.05),且观察组患者TC、TG水平均低于对照组(P<0.05)。治疗后患者肝、肾功能检查未出现明显变化,均未出现药物过敏反应和不耐受情况,无明显不良反应。结论:消脂方治疗湿热型NAFLD临床疗效好,能够显著改善患者中医症候评分和血脂水平,无明显不良反应,值得推广使用。
Objective：To explore the curative effect of ＂ Xiao-zhi Formula ＂treatment for non-alcoholic fatty liver（ NAFL） of damp-heat Syndrome type,provide reference for its treatment.Methods：A total of 100 patients with digestive internal medicine diagnosis and treatment of NAFLD,were randomly divided into control group（ 45 cases） and observation group（ 55 cases）.Observation group with clear heat lishi,liver spleen for therapeutic principles mesotherapy treatment,control group given spirit benefit liver treatment,during treatment for patients to strengthen activity,and proper diet.3 months after treatment,the clinical effectiveness and safety evaluation indicators were observed.Results：The observation group of patients treatment the total effective rate was 96.36%,significantly higher than that of control group 80.00%（ P〈0.05）.After treatment,two groups of patients was to reduce the symptoms integral（ P〈0.05）,and the observation group of TCM symptom score was significantly lower than control group（ P〈0.05）.After treatment,two groups of patients with TC,TG were significantly lower than before treatment（ P〈0.05）,and the observation group of patients with TC,TG levels are lower than the control group（ P〈0.05）.After treatment in patients with liver and renal function examination was a significant change,no drug allergy reaction occurred and intolerance,no obvious side effects.Conclusion：The mesotherapy treatment syndrome NAFLD clinical curative effect is good,can significantly improve patients with TCM symptom score and blood lipid levels,no obvious side effects,worthy of promotion of use.
出处
《世界中医药》
CAS
2016年第8期1524-1526,1529,共4页
World Chinese Medicine
基金
浦东新区中医中青年骨干人才培养项目(编号:PDZYXK-5-2014019)
关键词
非酒精性脂肪性肝病
消脂方
清热利湿
疏肝健脾
Non-alcoholic fatty liver
Xiao-zhi Formula
Clearing heat and removing dampness
Soothing liver and strengthening spleen
作者简介
徐森华（1980．08-），男，硕士研究生，主治医师，上海浦东人，研究方向：中西医结合治疗消化系统慢性疾病及恶性肿瘤，E—mail：xusenhua624@sina．com
通信作者：辜新奇（1979．02-），男，硕士研究生，主治医师，湖北省黄冈市人，研究方向：中西医结合消化内科，E-mail：jmxfxf@163．com
