摘要
目的 探讨血同型半胱氨酸（Hcy）、颈动脉粥样硬化与原发性高血压患者24h血压变异性（BPV）（收缩压、舒张压）之间的关系.方法 选取我院原发性高血压患者120例,根据血Hcy水平的不同分为3组：A组36例（Hcy＜ 15.0 μmol/L）,B组62例（15.0 μmol/L≤Hcy＜20.0 μmol/L）,C组22例（Hcy≥20.0 μmol/L）.分别测定其颈动脉厚度（IMT）、24h收缩压及舒张压、脉压标准差（SD）.结果 三组血压变异性随着Hcy的增高而增大,B组明显高于A组[（14.6±4.6） μmol/L比（12.6±3.4） μmol/L],C组明显高于B组、A组[（18.0±3.6）μmol/L比（14.6±4.6） μmol/L比（12.6±3.4） μmol/L].IMT厚度也随之增加,B组高于A组[（1.51 ±0.15）mm比（1.30±0.19）mm],C组高于B组、A组[（1.82±0.6）mm比（51.51 ±0.15）mm比（1.30±0.19）mm],组间比较差异有统计学意义（P＜0.05）.相关性分析提示,血Hcy水平与24 h BPV（收缩压、舒张压）之间存在相关性（r=0.570、0.512,P＜0.01）.IMT与24 h BPV呈直线相关（r=0.653、0.635,P＜0.01）,IMT与Hcy水平也呈直线相关（r=0.1252,P＜0.01）.结论 血压变异性增高可能与高Hcy及IMT相关,Hcy增高可能是造成动脉粥样硬化的重要因素.
Objective To investigate the blood homocysteine （Hcy）, carotid atherosclerosis in patients with essential hypertension and 24 hours blood pressure variability（BPV）（systolic, diastolic ） relationship between. Methods From 120 patients with essential hypertension, depending on the blood Hey levels, divided into three groups： A group of 36 cases （Hcy〈15.0 μmol/L）, group B of 62 cases （15.0 μmol/L〈Hcy〈20.0 μmol/L）, 22 cases in group C （t〉20.0 μmol/L） were measured carotid artery thickness（IMT） with 24-hour systolic and dias- tolic blood pressure, pulse pressure standard deviation （SD）. Results Three groups of blood pressure variability with Hcy increased variability increases, group B was significantly higher than that in group A[ （14.6±4.6）μmol/L vs （12.6±3.4）μmol/L], group C was significantly higher than group B, and group A [（18.0±3.6）μmol/L vs （14.6±4.6）μmol/L vs （12.6±3.4）μmol/L ]. IMT thickness also increased between the two groups group B was sig- nificantly higher than that in group A[ （1.51±0.15）ram vs （1.30±0.19）mm 1, group C was significantly higher than group B,and group A[（1.82＋0.6）mm vs （51.51±0.15）mm vs （1.30±0.19）mm]（P〈0.05）, statistically significant, correlation analysis showed that serum Hey levels with 24-hour BPV（systolic blood pressure, diastolic blood pres- sure between） correlation （r=0.570,0.512, P〈0.01）. IMT with 24-hour BPV linear correlation （r=0.653,0.635, P〈0.01 ） IMT and Hcy levels also showed a linear correlation （r=0.1252, P〈0.01 ）. Conclusion The increased blood pressure variability may be associated with high Hcy and 1MT-related, Hcy may cause increased an impor- tant factor for atheroselerosis.
出处
《中国心血管病研究》
CAS
2017年第1期65-68,共4页
Chinese Journal of Cardiovascular Research
