摘要
目的观察早期糖尿病肾病(EDN)动脉粥样硬化(AS)情况,并分析相关因素。方法选择EDN患者58例为观察组,对照组为58例单纯2型糖尿病(T2DM)患者,观察两组AS情况。同时将EDN分为非AS组、合并AS组,两组患者禁食12h后抽血送检糖化血红蛋白(HbA1c)、空腹血糖(FBG)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平,并测定血压、身高、体质量和计算体质量指数(BMI)。结果 EDN组颈动脉厚度,颈动脉硬化例数及颈动脉硬化率明显高于对照组,差异有统计学意义(P<0.05);EDN合并AS组在病程、BMI、HbA1c、FBG、TG、LDL-C、收缩压水平与EDN非AS组相比,差异有统计学意义(P<0.05)。结论 EDN较单纯T2DM更容易发生AS,EDN合并AS的危险因素可能为HbA1c、FBG、血压、TG、LDLC、BMI。
Objective To investigate the early diabetes nephropathy （EDN） and atherosclerosis （AS）,and a- nalysis the related factors. Methods 58 EDN patients were enrolled as an observation group and 58 type 2 diabetes mellits （T2DM） patients as the control group. These two groups were observed AS changes. The observation group was further divided into two groups with AS or not AS. We assessed glycosylated hemoglobin （HbAlc）, fasting blood glucose （FBG5, three acids glyceride （TG）, total cholesterol （TC）,high density lipoprotein cholesterol （HDL- C） ,low density lipoprotein cholesterol （LDL-C） among all the patients after 12-hour fasting,along with blood pres- sure,height, weight and body mass index （BMI） measurement. Results Carotid thickness and carotid atherosclerosis rate in observation group were significantly higher than the control group^Also the significant difference in terms of BMI, HbAlc. FBG.TG LDL-C and SBP between EDN with AS and EDN without AS was confirmed. Conclusion EDN is prone to have AS comparing to T2DM. And it is suggested that BMI, BP, HbAlc, FBG, TG, and LDL-C would be the potential risk factors for AS found in EDN patients. [
出处
《检验医学与临床》
CAS
2013年第22期3016-3017,共2页
Laboratory Medicine and Clinic
