摘要
目的:探讨原发性肾病综合征(PNS)患儿血管内皮生长因子(VEGF)、血同型半胱氨酸(Hcy)及其与急性肾损伤(AKI)的关系。方法:选取2016年7月~2019年7月本院收治的67例原发性肾病综合征患儿为研究对象。收集所有患儿的性别、年龄、身体质量指数(BMI)、24 h尿蛋白定量、血清肌酐(SCr)、肾小球滤过率估计值(eGFR)资料,检测VEGF、Hcy水平。采用Pearson相关性分析VEGF、Hcy水平与肾功能指标及AKI分期之间的的相关性。结果:PNS合并AKI组患儿的24 h尿蛋白定量、SCr、VEGF、Hcy水平明显高于PNS未合并AKI组,eGFR水平明显低于PNS未合并AKI组。VEGF水平与24 h尿蛋白定量、SCr、AKI分期呈正相关关系,与eGFR呈负相关关系;Hcy水平与24 h尿蛋白定量、SCr、AKI分期呈正相关关系,与eGFR呈负相关关系。结论:VEGF、Hcy水平与AKI关系密切,监测PNS患儿的VEGF、Hcy水平可能对监控患儿肾功能水平及AKI程度具有积极意义。
Objective To explore relationship between vascular endothelial growth factor(VEGF),serum homocysteine(Hcy)and acute kidney injury(AKI)in children with primary nephrotic syndrome(PNS).Methods A total of 67 PNS children who were admitted to the hospital from July 2016 to July 2019 were enrolled as study objects.The data such as gender,age,body mass index(BMI),24h urinary protein quantification(UPQ),serum creatinine(SCr)and estimated glomerular filtration rate(eGFR)of all children were collected.The levels of VEGF and Hcy were detected.Pearson correlation analysis was applied to analyze correlation of VEGF and Hcy levels with renal function indexes and AKI staging.Results The levels of 24h UPQ,SCr,VEGF and Hcy in PNS-AKI group were significantly higher than those in PNS-nonAKI group,while eGFR level was significantly lower than that in PNS-nonAKI group.VEGF level was positively correlated with 24h UPQ,SCr and AKI staging,while negatively correlated with eGFR.Hcy level was positively correlated with 24h UPQ,SCr and AKI staging,while positively correlated with eGFR.Conclusion The levels of VEGF and Hcy are closely related to AKI.Monitoring levels of VEGF and Hcy in PNS children may be of positive significance for monitoring renal function PNS of AKI severity.
作者
陈青
董泽伍
罗妍妍
Chen Qing;Dong Ze-wu;Luo Yan-yan(Huai'an First Hospital Affiliated to Nanjing Medical University,Huai'an 223300,China)
出处
《湖南师范大学学报（医学版）》
2020年第4期70-73,共4页
Journal of Hunan Normal University(Medical Sciences)
作者简介
通讯作者:陈青,E-mail:dei05e@163.com
