摘要
目的:研究左心衰竭患者血清MR-ProANP、NT-ProBNP含量与泵血功能、心室重构的相关性。方法:选择2013年5月~2016年5月期间在重庆市第九人民医院就诊的慢性心力衰竭患者104例作为研究的心衰组、同期在我院体检的95例健康志愿者作为研究的对照组。采集血清并检测MRProANP、NT-ProBNP以及心室重构相关分子的含量,行心脏彩色多普勒超声检查并测定心脏泵血功能和心肌重构的相关参数。结果:心衰组患者血清中MR-ProANP、NT-ProBNP、MMP2、MMP9、MMP10、PICP、PIIINP的含量以及超声参数IVSd、PWT、LVMI、MWS的水平均显著高于对照组,超声参数LAEF、LAPEF、LAAEF的水平均显著低于对照组;血清MR-ProANP、NT-ProBNP含量与超声参数IVSd、PWT、LVMI、MWS以及血清MMP2、MMP9、MMP10、PICP、PIIINP含量均呈正相关关系,与超声参数LAEF、LAPEF、LAAEF呈负相关关系,MR-ProANP与各指标的相关系数均高于NTProBNP。结论:左心衰竭患者血清MR-ProANP、NT-ProBNP含量与泵血功能、心室重构密切相关且MR-ProANP对泵血功能减退、心室重构增加的评估价值更大。
Objective：To study the correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodeling in patients with left heart failure.Methods：A total of 104 patients with chronic heart failure treated in our hospital between May 2013 and May 2016 were selected as the heart failure group of the research and 95 healthy volunteers receiving physical examination in our hospital over the same period were selected as the control group of the research.Serum was collected to detect the content of MR-ProANP,NT-ProBNP as well as ventricular remodeling-related molecules,and cardiac color Doppler ultrasonography was conducted to determine the heart pump function-and myocardial remodeling-related parameters.Results：Serum MR-ProANP,NT-ProBNP,MMP2,MMP9,MMP10,PICP and PⅢNP content as well as ultrasound parameters IVSd,PWT,LVMI,MWS levels of heart failure group were significantly higher than those of control group;ultrasound parameters LAEF,LAPEF and LAAEF levels were significantly lower than those of control group;serum MR-ProANP and NT-ProBNP content were positively correlated with ultrasound parameters IVSd,PWT,LVMI,MWS as well as serum MMP2,MMP9,MMP10,PICP and PⅢNP content,negatively correlated with ultrasound parameters LAEF,LAPEF and LAAEF,and the correlation coefficients of MR-ProANP with these indexes were all higher than those of NTProBNP.Conclusions：Serum MR-ProANP and NT-ProBNP content in patients with left heart failure are closely related to the pump function and ventricular remodeling,and MR-ProANP is more valuable for evaluating pump function decrease and ventricular remodeling increase.
出处
《海南医学院学报》
CAS
2017年第2期201-204,208,共5页
Journal of Hainan Medical University
基金
重庆市医学科研基金(2011A021013)~~
作者简介
何巧（1980-），女，重庆市人，主治医师，学士，联系电话：023—68219110、13883151898，电子信箱：hq429i4pavg@yeah．net。
[通讯作者]黄勇，地址：重庆市北碚区北京路5号，联系电话：15823502563。
