摘要
目的探讨布地奈德雾化吸入治疗老年哮喘患者的疗效及其对血清白细胞介素-2(IL-2)、白细胞介素-5(IL-5)和γ-干扰素(IFN-γ)的影响。方法老年哮喘患者166例分为观察组和对照组,每组83例。对照组患者给予吸氧、化痰、抗感染及静脉注射氨茶碱等对症治疗;观察组患者在此基础上给予布地奈德雾化吸入(布地奈德0.5 mg+2 m L生理盐水);比较2组患者治疗前后肺功能、血清IL-2、IL-5、IFN-γ水平及生活质量评分,并观察2组患者的不良反应。结果治疗后2组患者峰值呼气流速(PEF)、第1秒用力呼气量(FEV1)、FEV1/用力肺活量(FEV1/FVC)及血清IL-2、IFN-γ水平均较治疗前升高(P<0.05),IL-5水平较治疗前降低(P<0.05);观察组患者治疗后PEF、FEV1、FEV1/FVC及血清IL-2、IFN-γ水平显著高于对照组(P<0.05),且IL-5水平显著低于对照组(P<0.05)。治疗后2组患者临床症状和生活质量评分较治疗前均显著降低(P<0.05),且观察组患者临床症状和生活质量评分显著低于对照组(P<0.05)。2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论雾化吸入布地奈德能够显著提高老年哮喘患者的肺功能,改善生活质量,这可能与布地奈德能调节Th1/Th2的平衡有关。
Objective To explore the effect of budesonide inhalation in treating elderly patients with asthma and its effect on the levels of serum interleukin-2 （ IL-2 ） , interleukin-5 （ IL-5 ） and interferon-y （IFN-γ）. Methods One hundred and sixty-six elderly patients with asthma were randomly divided into control group and observation group, with 83 cases in each goup. The patients in control group were given oxygen, expectorant, anti infection, intravenous aminophylfine and other symptomatic treatment while the patients in observation group were given budesonide inhalation （ budesonide O. 5 mg ＋ 2 mL saline） on the basis of the treatment of control group. The changes of lung function,the levels of serum IL-2, IL-5 ,IFN-γ and quality of life scores and adverse reaction of two groups were recorded and compared before and after treatment. Results The levels of lung function parameters of peak expiratory flow （PEF） ,forced expiratory volmne in one second（ FEV1 ） and FEV1/forced vital capacity （FVC）, IL-2 and IFN-γ in the two groups after treatment were significantly higher than those before treatment （ P 〈 0. 05 ）, while the level of IL-5 was significantly lower than that before treatment in the two groups （ P 〈 0.05 ）. The levels of lung function parameters of PEF,FEV1 and FEV1/FVC,IL-2 and IFN-γ in the observation group after treatment were significantly higher than that in control group（ P 〈 0.05 ） ,while the level of IL-5 decreased more significantly in the observation group than that in control group（P 〈 0. 05）. Asthma control test score and score of St. Georges respiratory questionnaire after treatment were significantly lower than those before treatment in the two groups（P 〈 0. 05 ）. And the asthma control test score and score of St. Georges respiratory questionnaire after treatment in the observation were significantly lower than those in control group （ P 〈 0.05 ）. The adverse reaction between two groups had no significant difference （ P 〉 0.05 ）. Conclusions Budesonide aerosol inhalation treatment can significantly improve lung function and the quality of life of elderly patients with asthma. This may be related with the effect of budesonide on the balance of Th1/Th2.
作者
姚丽霞
YAO Li-xia(Department of Internal Medicine, the People＇s Hospital of Dongxihu District of Wuhan City, Wuhan 430000, Hubei Province, Chin)
出处
《新乡医学院学报》
CAS
2016年第1期61-63,共3页
Journal of Xinxiang Medical University
作者简介
姚丽霞（1973-），女，湖北武汉人，硕士，副主任医师，研究方向：慢性阻塞性肺疾病及重症肺炎等呼吸系统疾病。
