摘要
脊柱后纵韧带骨化的发生是由环境、基因等多因素造成的。随着基因学研究的深入,目前认为基因突变是诱发后纵韧带骨化的重要因素。尽管目前在后纵韧带骨化疾病的基因学研究方面取得了一定的进展,但是仍然还未有确切基因显示与后纵韧带骨化关系密切,后纵韧带骨化的发病机制还需要进一步的探索。
The ossification of the posterior longitudinal ligament (OPLL) is caused by environmental, genetic and other factors. With the development of genomics research, researchers have found that mutations are important factors inducing OPLL. Despite the genomies research on OPLL has made important advances, no highly correlation has been found between OPLL and the exact single nucleotide polymorphisms (SNPs) loci. The pathogenesis of OPLL needs further exploration.
出处
《中国微创外科杂志》
CSCD
北大核心
2016年第9期848-851,共4页
Chinese Journal of Minimally Invasive Surgery
基金
国家自然科学基金(81472041)
关键词
后纵韧带
骨化
基因学
Posterior longitudinal ligament
Ossification
Genetics
作者简介
通讯作者,E-mail:xgspine@sina.com