摘要
目的研究小儿肺炎患者在临床治疗中,阿奇霉素的用药安全性和有效性。方法将成都市第一人民医院儿科收治的小儿肺炎患儿120例作为研究对象,随机分为实验组和对照组。实验组采用阿奇霉素治疗,对照组采用红霉素治疗。观察两组患儿的临床治疗效果,以及不良反应情况。结果试验组患儿治疗后治愈、好转共计55例,总有效率为91.7%,高于对照组,两组比较,差异有统计学意义(P<0.05);患儿体温正常、咳嗽缓解、肺部啰音消失等症状恢复时间均短于对照组,两组比较,差异有统计学意义(P<0.05);用药中发生恶心呕吐、头晕、腹泻、皮肤过敏等不良反应共计5例,发生率为8.3%,和对照组相比,差异有统计学意义(P<0.05)。结论小儿肺炎应用阿奇霉素进行治疗效果确切,具有治疗有效率高、不良反应少、症状恢复时间短的特点,有利于患儿预后,如无禁忌可优先选用。
Objective To research the safety and effectiveness of azithromycin in clinical treatment of children with pneumonia. Methods A total of 120 children with pneumonia were selected from Department of Pediatrics in the hospital and randomly divided into two groups. The children in experimental group were treated by azithromycin, while the children in control group were treated by erythromycin. The clinical curative effects and adverse reactions in the two groups were observed. Results In experimental group, 55 children were cured or improved, the total effective rate was 91.7% , which was statistically significantly higher than that in control group （P〈0. 05 ） ; the recovery time of clinical symptoms （ body temperature, cough, and pulmonary rales ） in experimental group was statistically significantly shorter than that in control group （P〈0. 05 ） ; the incidence rate of adverse reactions （nausea, vomiting, dizziness, diarrhea, skin allergies） in experimental group was 8.3% （five children） , compared with control group, there was statistically significant difference （P〈0. 05 ） . Conclusion The clinical effect of azithromycin in treatment of children with pneumonia is exact, azithromycin has the advantages of high effectiveness, few adverse reactions, short recovery time of symptoms, the drug is conducive to prognosis of the children, which may be preferred if the children have no contraindieations.
出处
《中国妇幼保健》
CAS
2016年第17期3520-3522,共3页
Maternal and Child Health Care of China
关键词
小儿肺炎
阿奇霉素
临床效果
用药安全性
Child with pneumonia
Azithromycin
Clinical effect
Drug safety
