摘要
目的探讨小剂量雌激素联合孕激素对围绝经期综合征患者137例的临床疗效。方法按照随机数字表法将2014年12月至2015年12月北京市平谷区医院妇科收治的137例围绝经期综合征患者分为两组,对照组在常规对症治疗基础上给予小剂量雌激素治疗,观察纽在对照组治疗基础上联合孕激素治疗。比较两组治疗后的临床疗效及安全性。结果两组治疗后的LH、E2、FSH水平均较治疗前明显改善,且观察组改善的幅度大于对照组,差异均有统计学意义(t值分别为-6.89、16.06、-7.57,均P<0.001)。观察组临床疗效优于对照组,差异有统计学意义(Z=-2.004,P<0.05)。治疗期间,两组患者乳房肿痛、阴道出血、阴道瘙痒以及乳腺增生的发生率比较,差异无统计学意义(P>0.05),两组患者治疗后的子宫内膜厚度均大于治疗前,差异有统计学意义(t值分别为-6.56、-8.92,均P<0.001),两组患者治疗前后的子宫内膜厚度分别比较,差异无统计学意义(t值分别为1.186、-1.635,均P>0.05)。结论小剂量雌激素联合孕激素能明显缓解围绝经期综合征患者的临床症状,提高治疗效果,且安全性高,有临床推广应用价值。
Objective To explore the clinical efficacy of low dose estrogen combined with progesterone in the treatment of patients with menopausal syndrome. Methods Totally 137 patients with menopausal syndrome admitted in Pinggu District Hospital from December 2014 to December 2015 were divided into two groups according to random number table method. Control group was given low dose estrogen treatment based on conventional therapy, while the observation group was given low dose of progesterone based on the treatment for the control group. Comparisons of clinical efficacy and safety between two groups were conducted. Results The LH, E2 and FSH levels of two groups were significantly improved after treatment, and the improvement in the observation group was more than that in the control group with significant difference （ t value was - 6.89, 16.06 and - 7.57, respectively, all P 〈 0. 001 ）. The clinical efficacy in the observation group was better than that in the control group, and the difference was statistically significant （ Z = - 2. 004, P 〈 0.05 ）. During the treatment, the incidence of breast pain, vaginal bleeding, vaginal itching and hyperplasia of mammary glands between two groups was not statistically different （ P 〉 0.05 ）. After treatment, the endometrial thickening in two groups was greater than that before treatment, and the difference was significant （t value was -6.56 and -8.92, respectively, both P 〈 0. 001 ）. Before and after treatment, the difference in endometrial thickening between two groups was not found respectively （t value was 1. 186 and - 1. 635, respectively, both P 〉 0.05 ）. Conclusion Low dose estrogen combined with progesterone can significantly relieve the clinical symptoms of patients with menopausal syndrome, and improve treatment effect, which has high safety. So it has clinical application value.
出处
《中国妇幼健康研究》
2016年第3期314-316,共3页
Chinese Journal of Woman and Child Health Research
作者简介
杨静（1980-），女，主治医师，主要从事妇产科临床工作。
[通讯作者]高凤霞，副主任医师。
