摘要
目的分析更年期综合征患者接受激素替代疗法的临床效果与安全性。方法2019年6月至2020年12月选取赣州市妇幼保健院收治的绝经后存在更年期综合征症状的患者60例为研究对象,分为参照组(n=30,常规对症治疗)与试验组(n=30,激素替代疗法),对两组患者治疗前和治疗后的Kupperman评分、激素水平、子宫内膜厚度、不良反应发生情况进行对比分析。结果试验组患者治疗后Kupperman评分低于参照组(P<0.05)。试验组患者治疗后血清雌二醇水平高于参照组,促卵泡激素、促黄体生成素水平低于参照组(P<0.05);两组患者治疗后血清雌二醇水平高于治疗前,促卵泡激素、促黄体生成素水平低于治疗前(P<0.05)。两组患者治疗后子宫内膜厚度均高于治疗前(P<0.05),试验组治疗后子宫内膜厚度高于参照组(P<0.05)。试验组不良反应发生率〔6.7%(2/30)〕低于参照组〔16.7%(5/30)〕(χ^(2)=2.963,P=0.085)。结论在更年期综合征患者治疗中,运用激素替代疗法,能够使治疗效果进一步提升,减少不良反应的发生率。
Objective Analyze the clinical effect and safety of hormone replacement therapy in patients with menopausal syndrome.Methods 60 postmenopausal patients with menopausal syndrome symptoms admitted to Ganzhou Maternity and Child Health Hospital were selected as the research objects from June 2019 to December 2020.and they were divided into the reference group(n=30,conventional symptomatic treatment)and the experimental group(n=30,hormone replacement therapy).The Kupperman score,hormone levels,endometrial thickness,and adverse reactions of the two groups of patients before and after treatment were compared and analyzed.Results After treatment,the Kupperman score of the experimental group was lower than that of the reference group(P<0.05).After treatment,serum estradiol levels in the test group were higher than those in the reference group,and follicle-stimulating hormone and luteinizing hormone levels were lower than those in the reference group(P<0.05);after treatment,the serum estradiol levels in the two groups were higher than those before treatment.Follicle hormone and luteinizing hormone levels were lower than before treatment(P<0.05).The endometrial thickness of the two groups of patients after treatment was higher than that before treatment(P<0.05),and the endometrial thickness of the test group after treatment was higher than that of the reference group(P<0.05).The incidence of adverse reactions in the experimental group〔6.7%(2/30)〕is lower than that in the reference group〔16.7%(5/30)〕(χ^(2)=2.963,P=0.085).Conclusion In the treatment of patients with menopausal syndrome,the use of hormone replacement therapy can further enhance the therapeutic effect and reduce the incidence of adverse reactions.
作者
周林菊
ZHOU Linju(Department of Women's Health,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China)
出处
《中国全科医学》
CAS
北大核心
2021年第S02期88-90,共3页
Chinese General Practice
关键词
更年期综合征
激素替代疗法
治疗结果
安全性
Climacteric syndrome
Hormone replacement therapy
Treatment outcome
Safety
