摘要
目的评价羟苯磺酸钙和黄葵胶囊联合治疗老年早期糖尿病肾病(DN)的疗效。方法入选DN患者96例,随机分为治疗组和对照组,两组控制血糖方法相同。对照组48例口服黄葵胶囊(2.5 g/次,3次/d),治疗组48例口服羟苯磺酸钙(500 mg,3次/d)并联合黄葵胶囊(2.5 g/次,3次/d),均治疗12 w,观察治疗前后两组收缩压(SBP)、糖化血红蛋白(Hb A1c)、血肌酐(Scr)、尿素氮(BUN)、血清胱抑素(Cys)-C、内皮素(ET)及尿白蛋白排泄率(UAER)的变化。结果两组患者治疗前后SBP、Scr、BUN水平无明显变化(P>0.05);与治疗前相比,两组治疗后Hb A1c、Cys-C、ET、UAER均下降(P<0.05);与对照组比较,治疗组治疗后Cys-C和ET、UAER下降更为显著(P<0.05)。结论羟苯磺酸钙和黄葵胶囊联合治疗老年早期DN能有效降低Cys-C、ET,且能降低UAER,能有效逆转或延缓早期DN进展。
Objective To evaluate the effect of calcium dobesilate combined with okra capsule treatment on the elderly patients with early diabetic nephropathy（ DN）. Methods 96 elderly patients with early DN were randomly divided into treatment and control groups. 48 cases of the control group were given okra capsule 2. 5 g tid,the treatment group of 48 cases of was given calcium dobesilate 500 mg tid combined with okra capsule,two groups were treated for 12 weeks. Before and after treatment,the levels of systolic blood pressure（ SBP）,glycosylated hemoglobin（ Hb A1c）,serum creatinine（ Scr）,blood urea nitrogen（ BUN）,serum cystatin（ Cys-C）,endothelin（ ET） and urinary albumin excretion rate（ UAER） were observed. Results The levels of SBP,Scr and BUN had no significant changes in two groups before and after treatment（ P〉0. 05）. Compared with before treatment,the levels of Hb A1 c,Cys-C,ET and UAER were decreased in two groups after treatment（ P〈0. 05）. Compared with those of control group,the levels of Cys-C,ET,UAER were decreased significantly in treatment group after treatment（ P〈0. 05）. Conclusions Calcium dobesilate and okra capsule could effectively reverse or delay the progression of early DN by reducing the Cys C,ET,and UAER.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2016年第4期834-836,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金面上项目(81170823)
作者简介
李泉清（1962-），男，主任医师，主要从事糖尿病肾病研究。
通讯作者：王华（1972-），女，博士，副教授，硕士生导师，主要从事糖尿病肾病研究。
