摘要
目的:探讨红细胞分布宽度(RDW)对进展性卒中(SIP)的预测价值。方法:连续入选急性缺血性卒中患者428例,根据是否发生SIP分为SIP组60例和非SIP组368例,单因素分析比较2组间常见危险因素及RDW、hs-CRP的差异性,采用Logistic回归分析相关危险因素对SIP的影响,对RDW、hs-CRP及颈动脉硬化斑块稳定性进行相关性分析,分别建立RDW和hs-CRP预测SIP的受试者工作特征(ROC)曲线。结果:单因素分析提示,年龄、RDW、hs-CRP及不稳定颈动脉斑块比例在2组间差异有统计学意义(P<0.05)。Logistic回归分析上述指标均为SIP的独立危险因素,相关分析提示RDW、hs-CRP及颈动脉不稳定斑块之间具有相关性。RDW及hs-CRP预测SIP的ROC曲线下面积分别为0.857及0.723;最佳诊断界点分别为13.34%及4.73 mg/L,RDW对于预测SIP的诊断效能高于hs-CRP。结论:RDW水平与SIP的发生密切相关,可能可作为SIP的预测指标。
Objective： To explore the diagnostic value of red cell distribution width （RDW） in predicting stroke in progression （SIP）. Methods： Four hundred and twenty-eight eligible patients with acute ischemic stroke were consecutively enrolled, and divided into SIP group （n=60） and non-SIP group （n=368）. The cardiovascular risk factors, RDW levels and hs-CRP between the 2 groups were compared using univariate analysis. Furthermore, Lo-gistic regression was performed to determine the independent risk factors. The correaltions between RDW, hs-CRP and plaque stability were analyzed by correlation analysis.Receiver operator curve （ROC） test was used to deter-mine the predictive value of RDW and hs-CRP for SIP. Results： Univariate analysis revealed that there were signif-icant differences in age, RDW, hs-CRP and plaque stability between the two groups. Logistic regression con-firmed the above findings. RDW significantly correlated with hs-CRP and plaque unstability （P〈0.05）. The areas under ROC curve by RDW and hs-CRP were 0.857 and 0.723 respectively. The optimal threshold values were 13.34% for RDW and 4.73mg/L for hs-CRP respectively. The diagnostic significance of RDW was better than hs-CRP. Conclusion： The RDW level at admission is closely related to SIP, which may serve as a predictor for SIP.
出处
《神经损伤与功能重建》
2015年第5期390-393,共4页
Neural Injury and Functional Reconstruction
关键词
红细胞分布宽度
颈动脉粥样硬化斑块
进展性卒中
超敏
C
反应蛋白
red blood cell distribution width
carotid atherosclerotic plaque
stroke in progression
high-sensitivi-ty C-reactive protein
作者简介
通讯作者冯娟fengj@sj—hospital．org
