摘要
目的通过光学比浊法(LTA)检测血小板功能评价阿司匹林疗效,并对影响阿司匹林疗效的可能风险因素进行评估。方法收集2018年11月至2020年1月于北京天坛医院住院治疗的急性缺血性脑卒中患者186例,根据血小板聚焦率结果将其划分为阿司匹林抵抗组31例,阿司匹林非抵抗组155例,比较两组患者的临床资料及实验室指标,并采用Logistic回归进行阿司匹林抵抗的风险因素分析。结果与阿司匹林非抵抗组比较,阿司匹林抵抗组患者红细胞分布宽度(RDW)参数RDW-SD及RDW-CV偏大,差异有统计学意义(P<0.05),既往有吸烟史及脑卒中病史的比例更高(P<0.05)。Logistic回归分析显示吸烟史(OR=4.918,95%CI:1.657~14.590,P=0.004)和RDW-CV(OR=1.397,95%CI:1.070~1.823,P=0.014)为阿司匹林抵抗的独立风险因素。结论吸烟史和高水平RDW-CV为阿司匹林抵抗的独立风险因素,二者有助于早期识别阿司匹林抵抗高风险人群。
Objective To evaluate the efficacy of aspirin by detecting platelet function by optical turbidimetry(LTA),and to evaluate the possible risk factors leading to the efficacy of aspirin.Methods A total of 186 patients with acute ischemic stroke who were hospitalized in Beijing Tiantan Hospital from November 2018 to January 2020 were collected.According to the platelet aggregation rate results,they were divided into aspirin-resistant group(n=31)and aspirin-non-resistant group(n=155).The clinical data and laboratory indicators of the two groups of patients were analyzed and Logistic regression to analyze the risk factors of aspirin resistance was used.Results Compared with the aspirin non-resistant group,the red blood cell distribution width(RDW)parameters RDW-SD and RDW-CV of patients in the aspirin resistant group were larger,and the difference was statistically significant(P<0.05).The proportion of those with a history of smoking and stroke was higher(P<0.05).Logistic regression analysis showed that smoking history(OR=4.918,95%CI:1.657-14.590,P=0.004)and RDW-CV(OR=1.397,95%CI:1.070-1.823,P=0.014)were independent risk factors for aspirin resistance.Conclusion Smoking history and high levels of RDW-CV constitute independent risk factors for aspirin resistance,and both help to identify people at high risk of aspirin resistance early.
作者
李虓
张丽敏
孙越红
王丹
史从宁
张国军
LI Xiao;ZHANG Limin;SUN Yuehong;WANG Dan;SHI Congning;ZHANG Guojun(Department of Clinical Laboratory,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100070,China;Beijing Engineering Research Center of Immunological Reagents Clinical Research,Beijing 100070,China)
出处
《国际检验医学杂志》
CAS
2020年第17期2100-2103,2111,共5页
International Journal of Laboratory Medicine
基金
北京天坛医院院青年科学基金(2016-YQN-09)
首都医科大学科研培育基金(PYZ2017067)。
关键词
光学比浊法
红细胞分布宽度
缺血性脑卒中
阿司匹林抵抗
optical turbidimetry
red blood cell distribution width
ischemic stroke
aspirin resistance
作者简介
李虓,男,主管技师,主要从事临床基础检验;通信作者:张国军,E-mail:tiantanzgj@163.com。
